Gordon Smyth Home - Publications to 2002

Publications since 2003

2026

• Thomas T, Malelang S, Yang Y, Bergamasco MI, Kueh AJ, Garnham AL, Ranathunga N, Smyth GK, Voss AK (2026). The roles of the acetyltransferase domains of the KAT6A and KAT6B in vivo. Development. (Accepted 12 May 2026)
• Voss AK, Eccles S, Wichmann J, Abeysekera W, Bergamasco MI, Garnham AL, Ranathunga N, Yang Y, Bowden R, Smyth GK, Thomas T (2026). KAT6A is essential for developmental control gene expression in neural stem and progenitor cells. PLOS Genetics. [DOI] (Accepted 28 Apr 2026, Epub 4 May 2026)
• Eccles S, Vanyai HK, Bergamasco MI, Malelang S, Pehlivanoglu H, Garnham AL, Ranathunga N, Blewitt ME, Vogel AP, Smyth GK, Hannan AJ, Thomas T*, Voss AK* (2026). Acetyl-carnitine improves hyperactivity and learning deficits in KAT6A haploinsufficient mice. Life Science Alliance 9(5), lsa.202503549. [DOI] (Accepted 8 Feb 2026, Published 17 Feb 2026)
• Jin X, Putri GH, Cheng J, Asselin-Labat M-L, Smyth GK, Belinda Phipson B (2026). jazzPanda: A hybrid approach to find spatial marker genes in imaging-based spatial transcriptomics data bioRxiv 2026.02.13.705867. [DOI] (Published 16 Feb 2026)
• Ashayeripanah M, Coughlan H, Zhang S, Yan J, Bandala-Sanchez E, Lin D, Tullett KM, Naik SH, Groom JR, Lahoud MH, Belz GT, Huntington ND, Smyth GK, Nutt SL*, Chopin M* (2026). Interleukin-4 selectively expands functional type 1 conventional dendritic cells from bone marrow progenitors. Cell Reports 45(1), 116772. [DOI] (Accepted 29 Nov 2025, Epub 24 Dec 2025, Published 27 Jan 2026)
• Corso LD, River ISa, Al Halawani A, Gerak CAN, Gannon D, Ozaydin O, Li M, Thyagarajan K, Niezabitowski L, Chua NK, Tan W, Wudy SI, McLysaght A, Smyth GK, Shakeel S, Feltham R, Vervoort SJ (2026). INTS12 bridges Integrator and NELF to prevent the release of non-processive RNA polymerase II complexes. bioRxiv. [DOI] (Published 17 Jan 2026)

2025

• Baldoni PL#, Chen L#, Li M, Chen Y, Smyth GK (2025). Dividing out quantification uncertainty enables assessment of differential transcript usage with limma and edgeR. Nucleic Acids Research 53(22), gkaf1305. [DOI] (Accepted 22 Oct 2025, Epub 8 Dec 2025, Published 11 Dec 2025)
• Tan W, Park J, Venugopal H, Lou J, Dias PS, Baldoni PL, Moon KW, Dite TA, Keenan CR, Gurzau AD, Lee J, Johanson T, Leis A, Yousef J, Vaibhav V, Dagley LF, Ang CS, Corso LD, Davidovich C, Vervoort SJ, Smyth GK, Blewitt ME, Allan RS, Hinde E, D'Arcy S, Ryu JK*, Shakeel S* (2025). MORC2 is a phosphorylation-dependent DNA compaction machine. Nature Communications 16, 5606. [DOI] (Accepted 30 May 2025, Published 1 Jul 2025)
• Nie J, Tellier J, Tarasova I, Nutt SL*, Smyth GK* (2025). T2T-CHM13 vs hg38: accurate identification of immunoglobulin isotypes from scRNA-seq requires a genome reference matched for ancestry. NAR Genomics and Bioinformatics 7(2), lqaf074. [PubMed] [DOI] (Accepted 19 May 2025, Published 11 Jun 2025)
• Pascual R, Cheng J, De Smet AH, Capaldo BD, Tsai M, Kordafshari S, Vaillant F, Song X, Giner G, Milevskiy MJG, Jackling FC, Pal B, Dite T, Yousef J, Dagley LF, Smyth GK, Fu N, Lindeman GJ, Chen Y, Visvader JE (2025). Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis. EMBO Journal 44(11), 3266-3300. [PubMed] (Accepted 14 Mar 2025, Epub 11 Apr 2025, Published 2 Jun 2025)
• Nie J, Tellier J, Tarasova I, Nutt SL*, Smyth GK* (2025). T2T-CHM13 vs GRCh38: accurate identification of immunoglobulin isotypes from scRNA-seq requires a genome reference matched for ethnicity. bioRxiv. [DOI] (Published 25 May 2023, Revised 22 Mar 2025)
• Li M, Cobbold SA, Smyth GK (2025). Quantification and differential analysis of mass spectrometry proteomics data with probabilistic recovery of information from missing values. bioRxiv. [DOI] (Published 29 Apr 2025)
• Baldoni PL#, Chen L#, Li M, Chen Y, Smyth GK (2025). Dividing out quantification uncertainty enables assessment of differential transcript usage with limma and edgeR. bioRxiv. [DOI] (Published 14 Apr 2025. Revised 28 Aug 2025, 29 Sep 2025, and 15 Oct 2025)
• Bergamasco MI, Ogier JM, Garnham AL, Whitehead L, Rogers K, Smyth GK, Burt RA, Voss AK, Thomas T (2025). Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development. Developmental Biology 520, 141-154. [DOI] [PubMed] (Epub 19 Jan 2025, Published 1 Apr 2025)
• Chin HS*, Cheng J, Hsu SH, Lum GG, Zaldivia MTK, Guo F, Mallavarapu K, Jackling FC, Yang J, Tan JSL, Sampath P, Barker N, Smyth GK, Lindeman GJ, Strasser A, Visvader JE, Chen Y, Chen T, Fu NY* (2025). MCL1 safeguards activated hair follicle stem cells to enable adult hair regeneration. Nature Communications 16, 2829. [PubMed] (Accepted 10 Mar 2025, Published 22 Mar 2025)
• Bergamasco MI, Yang Y, Garnham AL, Sheikh BN, Smyth GK, Voss AK*, Thomas T* (2025). KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan. Nature Communications 16(1), 1958. [PubMed] (Accepted 11 Feb 2025, Published 25 Feb 2025)
• Bergamasco MI, Ozturk E, Casillas-Espinosa PM, Garnham AL, Abeysekera W, Wimmer VC, Rajasekhar P, Vanyai HK, Whitehead L, Blewitt ME, Rogers K, Vogel AP, Hannan AJ, Smyth GK, Jones NC, Thomas T*, Voss AK* (2025). KAT6B overexpression in mice causes aggression, anxiety and epilepsy. iScience 28(3), 111953. [PubMed] (Accepted 31 Jan 2025, Published 11 Feb 2025)
• Bergamasco MI, Abeysekera W, Garnham AL, Hu Y, Li-Wai-Suen CSN, Sheikh BN, Smyth GK, Thomas T*, Voss AK* (2025). KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brain. Life Science Alliance 8(2), e202402969. [PubMed] (Accepted 4 Nov 2024, Epub 13 Nov 2024, Published 1 Feb 2025)
• Ang CW, Arandjelovic P, Cheng J, Yang J, Guo F, Yu Y, Nelameham S, Whitehead L, Li J, Silver D, Barker N, Visvader JE, Chow P, Smyth GK, Chen Y, Virshup D, Fu NY (2025). Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries. Cell Reports 44(1), 115093. [PubMed] (Accepted 29 Nov 2024, Epub 24 Dec 2024, Published 28 Jan 2025)
• Chen Y, Chen L, Lun ATL, Baldoni PL, Smyth GK (2025). edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets. Nucleic Acids Research 53(2), gkaf018. [DOI] (Accepted 6 Jan 2025, Epub 22 Jan 2025, Published 27 Jan 2025)
• Cheng J, Jin X, Smyth GK*, Chen Y* (2025). Benchmarking cell type annotation methods for 10x Xenium spatial transcriptomics data. BMC Bioinformatics 26, Article 22. [PubMed] (Accepted 9 Jan 2025, Published 20 Jan 2025)

2024

• Dawson CA#, Milevskiy MJG#, Capaldo BD, Yip RKH, Song X, Vaillant F, Prokopuk L, Jackling FC, Smyth GK, Chen Y, Lindeman GJ, Visvader JE (2024). Hormone-responsive progenitors have a unique identity and exhibit high motility during mammary morphogenesis. Cell Reports 43(12), 115073. [PubMed] (Accepted 26 Nov 2024, Epub 17 Dec 2024, Published 24 Dec 2024)
• Hunter B#, Li M#, Parker BL, Koay YC, Harney DJ, Pearson E, Jacob Cao, Chen GT, Guneratne O, Smyth GK, Larance M, O'Sullivan JF*, Lal S* (2024). Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies. Communications Biology 7(1), 1666. [PubMed] (Accepted 22 Nov 2024, Published 19 Dec 2024)
• Baldoni PL, Chen L, Smyth GK (2024). Faster and more accurate assessment of differential transcript expression with Gibbs sampling and edgeR v4. NAR Genomics and Bioinformatics 6(4), lqae151. [DOI] (Accepted 16 Oct 2024, Epub 4 Nov 2024, Published 1 Dec 2024)
• McRae HM#, Leong MPY#, Bergamasco MI, Garnham AL, Hu Y, Corbett MA, Whitehead L, El-Saafin F, Sheikh BN, Wilcox S, Hannan AJ, Gécz J, Smyth GK, Thomas T*, Voss AK* (2024). Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson-Forssman-Lehmann intellectual disability syndrome. PLOS Genetics 20(10), e1011428. [PubMed] (Accepted 30 Sep 2024, Published 15 Oct 2024)
• Lieschke E, Thomas AF, Kueh A, Atkin-Smith G, Baldoni PL, La-Marca JE, Young S, Huang AS, Ross A, Whelan L, Kaloni D, Tai L, Smyth GK, Herold MJ, Hawkins E, Strasser A*, Kelly GL* (2024). Mouse models to investigate in situ cell fate decisions induced by TP53 and other factors. EMBO Journal 43(19), 4406-4436. [PubMed] (Accepted 12 Jul 2024, Epub 19 Aug 2024, Published 1 Oct 2024)
• Tan W, Park JV, Venugopal H, Lou JQ, Dias PS, Baldoni PL, Dite T, Moon KW, Keenan CR, Gurzau AD, Leis A, Yousef J, Vaibhav V, Dagley LF, Ang CS, Corso L, Davidovich C, Vervoort SJ, Smyth GK, Blewitt ME, Allan RS, Hinde E, Sheena D'Arcy S, Ryu JK, Shakeel S (2024). MORC2 phosphorylation fine tunes its DNA compaction activity. bioRxiv 2024.06.27.600912. [DOI] (Published 28 Jun 2024)
• Baldoni PL, Chen L, Smyth GK (2024). Faster and more accurate assessment of differential transcript expression with Gibbs sampling and edgeR v4. bioRxiv 2024.06.25.600555. [DOI] (Published 28 Jun 2024, Revised 12 Oct 2024)
• Keenan CR#, Coughlan HD#, Iannarella N, del Fierro AT, Keniry A, Johanson TM, Chan WF, Garnham AL, Whitehead LW, Blewitt ME, Smyth GK*, Allan RS* (2024). Suv39h-catalysed H3K9me3 is critical for euchromatic genome organisation and the maintenance of gene transcription. Genome Research 34(4), 556-571. [PubMed] (Accepted 3 Apr 2024, Epub 6 May 2024, Published 15 May 2024)
• Hunter B#, Li M#, Parker BL, Koay YC, Harney DJ, Pearson E, Cao J, Chen GT, Guneratne O, Smyth GK, Larance M, O'Sullivan JF*, Lal S* (2024). Ventricle-specific myocardial protein and metabolite characterisation in healthy humans, with differential regulation in end-stage cardiomyopathies. medRxiv. [DOI] (Epub 22 Apr 2024)
• Bergamasco MI, Ranathunga N, Abeysekera W, Li-Wai-Suen C, Garnham AL, Willis SN, McRae HM, Yang Y, D'Amico A, Di Rago L, Wilcox S, Nutt SL, Alexander WS, Smyth GK, Voss AK*, Thomas T* (2024). The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function. Stem Cell Reports 19(4), 469-485. (Accepted 22 Feb 2024, Epub 21 Mar 2024, Published 9 Apr 2024) [PubMed]
• Bergamasco MI, Vanyai HK, Garnham AL, Geoghegan ND, Vogel AP, Eccles S, Rogers KL, Smyth GK, Blewitt ME, Hannan AJ, Thomas T*, Voss AK* (2024). Increasing histone acetylation improves sociability and restores learning and memory in KAT6B-haploinsufficient mice. Journal of Clinical Investigation 34(7), e167672. [PubMed] (Accepted 26 Jan 2024, Published 1 Apr 2024)
• Mah SYY, Vanyai HK, Li-Wai-Suen CSN, Garnham AL, Wynn J, Bergamasco MI, Malelang S, Wilcox S, Biben C, Smyth GK, Thomas T*, Voss AK* (2024). ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development. Development 151(5), dev202617. [PubMed] (Accepted 31 Jan 2024, Epub 6 Mar 2024, Published 1 Mar 2024)
• Ashayeripanah M, Vega-Ramos J, Fernandez-Ruiz D, Valikhani S, Lun ATL, White JT, Young LJ, Yaftiyan A, Zhan Y, Wakim L, Caminschi I, Lahoud MH, Lew AM, Shortman K, Smyth GK, Heath WR, Mintern JD, Roquilly A*, Villadangos JA* (2024). Systemic inflammatory response syndrome triggered by blood borne pathogens induces prolonged dendritic cell paralysis and immunosuppression. Cell Reports 43(2), 113754. [PubMed] (Accepted 22 Jan 2024, Epub 13 Feb 2024, Published 27 Feb 2024)
• Baldoni PL#, Chen Y#, Hediyeh-zadeh S, Liao Y, Dong X, Ritchie ME, Shi W, Smyth GK (2024). Dividing out quantification uncertainty allows efficient assessment of differential transcript expression with edgeR. Nucleic Acids Research 52(3), e13. [DOI] (Accepted 19 Nov 2023, ePub 7 Dec 2023, Published 9 Feb 2024)
• Tellier J, Tarasova I, Nie J, Smillie CS, Fedele PL, Cao WHJ, Groom JR, Belz GT, Bhattacharya D, Smyth GK, Nutt SL (2024). Unraveling the diversity and functions of tissue-resident plasma cells. Nature Immunology 25(2), 330-342. [PubMed] (Accepted 14 Nov 2023, Epub 3 Jan 2024, Published 1 Feb 2024)
• Chen Y, Chen L, Lun ATL, Baldoni PL, Smyth GK (2024). edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets. bioRxiv 2024.01.21.576131. [DOI] (Posted 24 Jan 2024, Revised 24 Nov 2024)
• Joyce R#, Pascual R#, Heitink L, Capaldo BD, Vaillant F, Christie M, Tsai M, Surgenor E, Anttila CJA, Rajasekhar P, Jackling FC, Trussart M, Milevskiy MJG, Song X, Li M, Teh CE, Gray DHD, kConFab, Smyth GK, Chen Y, Lindeman GJ*, Visvader JE* (2024). Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers. Nature Cell Biology 26(1), 138-152. [PubMed] (Accepted 15 Nov 2023, Published 12 Jan 2024)

2023

• Cheng J, Smyth GK*, Chen Y* (2023). Unraveling the timeline of gene expression: A pseudotemporal trajectory analysis of single-cell RNA sequencing data (version 2). F1000Research 12, 684. [PubMed] (Submitted 30 May 2023, Published 10 Nov 2023)
• Dong X*, Du MRM, Gouil Q, Tian L, Jabbari JS, Bowden R, Baldoni PL, Chen Y, Smyth GK, Amarasinghe SL, Law CW, Ritchie ME* (2023). Benchmarking long-read RNA-sequencing analysis tools using in silico mixtures. Nature Methods 20(11), 1810-1821. [PubMed] (Accepted 25 Aug 2023, Epub 2 Oct 2023, Published 1 Nov 2023)
• Milevskiy MJG#, Coughlan HD#, Kane SR, Johanson TM, Kordafshari S, Chan WF, Tsai M, Surgenor E, Wilcox S, Allan RS, Chen Y, Lindeman GJ, Smyth GK, Visvader JE (2023). Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells. Cell Genomics 3(11), 100424. [PubMed] (Accepted 20 Sep 2023, Epub 8 Nov 2023, Published 16 Oct 2023)
• Baldoni PL#, Chen Y#, Hediyeh-zadeh S, Liao Y, Dong X, Ritchie ME, Shi W, Smyth GK (2023). Dividing out quantification uncertainty allows efficient assessment of differential transcript expression with edgeR. bioRxiv 2023.04.02.535231. [DOI] (Published 4 Apr 2023, Revised 15 Oct 2023)
• Arandjelovic P, Kim Y, Cooney JP, Preston SP, Doerflinger M, McMahon JH, Garner SE, Zerbato JM, Roche M, Tumpach C, Ong J, Sheerin D, Smyth GK, Anderson JL, Allison C, Lewin SR, Pellegrini M (2023). Venetoclax, alone and in combination with the BH3-mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice. Cell Reports Medicine 4(9), 101178. [PubMed] (Accepted 9 Aug 2023, Epub 30 Aug 2023, Published 19 Sep 2023)
• Cheng J, Smyth GK*, Chen Y* (2023). Unraveling the timeline of gene expression: A pseudo-temporal trajectory analysis of single-cell RNA sequencing data (version 1). F1000Research 12, 684. [DOI] (Published 15 Jun 2023)
• Abdulla H, Alserihi R, Flensburg C, Abeysekera W, Luo M, Gray DHD, Smyth GK, Alexander WS, Majewski IJ, McCormack MP (2023). Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition. Journal of Experimental Medicine 220(6), e20212383. [PubMed] (Accepted 22 Feb 2023, Epub 15 Mar 2023, Published 5 Jun 2023)
• Cheng J, Smyth GK*, Chen Y* (2023). Unraveling the timeline of gene expression: a pseudo-temporal trajectory analysis of single-cell RNA sequencing data. bioRxiv 2023.05.28.542618. [DOI] (Published 30 May 2023)
• Nie J, Tellier J, Tarasova I, Nutt SL*, Smyth GK* (2023). The T2T-CHM13 reference genome has more accurate sequences for immunoglobulin genes than GRCh38. bioRxiv 2023.05.24.542206. [DOI] (Published 25 May 2023)
• Dong X, Du MRM, Gouil Q, Tian L, Jabbari JS, Bowden R, Baldoni PL, Chen Y, Smyth GK, Amarasinghe SL, Law CW, Ritchie ME (2022). Benchmarking long-read RNA-sequencing analysis tools using in silico mixtures. bioRxiv 2022.07.22.501076. [DOI] (Published 22 Jul 2022, Revised 29 Jul 2022 and 18 May 2023)
• You Y, Dong X, Wee YK, Maxwell MJ, Alhamdoosh M, Smyth GK, Hickey PF, Ritchie ME*, Law CW* (2023). Modelling group heteroscedasticity in single-cell RNA-seq pseudo-bulk data. Genome Biology 24(1), 107. [PubMed] (Accepted 28 Apr 2023, Published 5 May 2023)
• Li M, Smyth GK (2023). Neither random nor censored: estimating intensity-dependent probabilities for missing values in label-free proteomics. Bioinformatics 39(5), btad200. [PubMed] (Accepted 12 Apr 2023, Epub 17 Apr 2023, Published 4 May 2023)
• Chan WF, Coughlan HD, Ruhle M, Iannarella N, Alvarado C, Groom JR, Keenan CR, Kueh AJ, Wheatley AK, Smyth GK, Allan RS*, Johanson TM* (2023). Survey of activation-induced genome architecture reveals a novel enhancer of Myc. Immunology and Cell Biology 101(4), 345-357. [PubMed] (Accepted 27 Jan 2023, Epub, 14 Feb 2023, Published 1 Apr 2023)
• Kueh AJ#, Bergamasco M#, Quaglieri A, Phipson B, Li-Wai-Suen CSN, Lönnstedt IM, Hu Y, Feng Z-P, Woodruff C, May RE, Wilcox S, Garnham AL, Snyder MP, Smyth GK, Speed TP, Thomas T*, Voss AK* (2023). Stem cell plasticity, acetylation of H3K14 and de novo gene activation rely on KAT7. Cell Reports 42(1), 111980. [PubMed] (Accepted 21 Nov 2022, Epub 14 Jan 2023, Published 31 Jan 2023)

2022

• Chan WF, Coughlan HD, Chen Y, Keenan CR, Smyth GK, Perkins AC, Johanson TM, Allan RS (2022). Activation of stably silenced genes by recruitment of a synthetic de-methylating module. Nature Communications 13(1), 5582. [PubMed] (Accepted 7 Sep 2022, Published 23 Sep 2022)
• Chan WF, Coughlan HD, Ruhle M, Iannarella N, Alvarado C, Groom JR, Keenan CR, Kueh AJ, Wheatley AK, Smyth GK, Allan RS*, Johanson TM* (2022). Survey of activation-induced genome architecture reveals a novel enhancer of Myc. bioRxiv 2022.09.14.508046. [DOI] (Published 20 Sep 2022)
• You Y, Dong X, Wee YK, Maxwell MJ, Alhamdoosh M, Smyth GK, Hickey PF, Ritchie ME, Law CW (2022). Modelling group heteroscedasticity in single-cell RNA-seq pseudo-bulk data. bioRxiv 2022.09.12.507511. [DOI] (Published 14 Sep 2022)
• Wichmann J, Pitt C, Eccles S, Garnham AL, Li-Wai-Suen CSN, May R, Allan E, Wilcox S, Herold MJ, Smyth GK, Monahan BJ, Thomas T, Voss AK (2022). Loss of TIP60 abolishes H2AZ lysine 7 acetylation and causes p53, INK4A and ARF-independent cell cycle arrest. Cell Death & Disease 13(7), 627. [PubMed] (Accepted 30 Jun 2022, Published 20 Jul 2022)
• Li M, Smyth GK (2022). Missing values are informative in label-free shotgun proteomics data: estimating the detection probability curve. bioRxiv 2022.07.02.498573. [DOI] (Published 4 Jul 2022)
• Haeusler GM, Garnham AL, Li-Wai-Suen CSN, Clark JE, Babl FE, Allaway Z, Slavin MA, Mechinaud F, Smyth GK, Phillips B, Thursky KA, Pellegrini M*, Doerflinger M* (2022). Blood transcriptomics identifies immune signatures indicative of infectious complications in childhood cancer patients with febrile neutropenia. Clinical & Translational Immunology 11(5), e1383. [PubMed] (Accepted 10 Mar 2022, Published 17 May 2022)
• El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-zadeh S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T*, Voss AK* (2022). Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death and Differentiation 29(5), 1013-1027. [PubMed] (Accepted 10 Mar 2022, Epub 31 Mar 2022, Published 1 May 2022)
• Studniberg SI, Ioannidis LJ, Utami RAS, Trianty L, Liao Y, Abeysekera W, Li-Wai-Suen CSN, Pietrzak HM, Healer J, Puspitasari AM, Apriyanti D, Coutrier F, Poespoprodjo JR, Kenangalem E, Andries B, Prayoga P, Sariyanti N, Smyth GK, Cowman AF, Price RN, Noviyanti R, Shi W, Garnham AL, Hansen DS (2022). Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria. Molecular Systems Biology 18(4), e10824. [PubMed] (Accepted 1 Apr 2022, Published 27 Apr 2022)
• Chen Y, Pal B, Lindeman GJ, Visvader JE, Smyth GK (2022). R code and downstream analysis objects for the scRNA-seq atlas of normal and tumorigenic human breast tissue. Scientific Data 9(1), 96. [PubMed] (Accepted 24 Feb 2022, Published 23 Mar 2022)
• Heitink L, Whittle JR, Vaillant F, Capaldo BD, Dekkers JF, Dawson CA, Milevskiy MJG, Tsai M, Chen HR, Christie M, Chen Y, Smyth GK, Herold MJ, Strasser A, Lindeman GJ*, Visvader JE* (2022). In vivo genome-editing screen identifies tumor suppressor genes that cooperate with Trp53 loss during mammary tumorigenesis. Molecular Oncology 16(5), 1119-1131. [PubMed] (Accepted 13 Dec 2021, Epub 9 Jan 2022, Published 1 Mar 2022)
• Bediaga NG, Garnham AL, Naselli G, Bandala-Sanchez E, Stone NL, Cobb J, Harbison JE, Wentworth JM, Ziegler AG, Couper JJ, Smyth GK, Harrison LC (2022). Cytotoxicity-related gene expression and chromatin accessibility define a subset of CD4+ T cells that mark progression to type 1 diabetes. Diabetes 71(3), 566-577. [PubMed] (Accepted 12 Dec 2021, Epub 7 Jan 2022, Published 1 Mar 2022)
• Yang Y, Kueh AJ, Grant ZL, Abeysekera W, Garnham AL, Wilcox S, Hyland CD, Di Rago L, Metcalf D, Alexander WS, Coultas L, Smyth GK, Voss AK*, Thomas T* (2022). The histone lysine acetyltransferase HBO1 regulates hematopoietic stem cell quiescence and self-renewal. Blood 139(6), 845-858. [PubMed] (Accepted 14 Oct 2021, Epub 1 Nov 2021, Published 10 Feb 2022)
• Heinlein M, Gandolfo LC, Zhao K, Teh CE, Nguyen N, Baell JB, Goldfarb Y, Abramson J, Wichmann J, Voss AK, Strasser A, Smyth GK, Thomas T, Gray DHD (2022). The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes and thymic tolerance. Science Immunology 7(67), eabb6032. [PubMed] (Accepted 22 Dec 2021, Published 21 Jan 2022)

2021

• Zotos D, Quast I, Li-Wai-Suen CSN, McKenzie CI, Robinson MJ, Kan A, Smyth GK, Hodgkin P, Tarlinton DM (2021). The distribution of cell cycle phases and zone composition change in concert in germinal centers, regulated by IL21. Nature Communications 12(1), 7160. [PubMed] (Accepted 19 Nov 2021, Published 9 Dec 2021)
• Chen Y, Pal B, Lindeman GJ, Visvader JE, Smyth GK (2021). R code and downstream analysis objects for the scRNA-seq atlas of human breast spanning normal, preneoplastic and tumorigenic states. bioRxiv. [DOI] (Published 1 Dec 2021)
• Yip RKH, Rimes JS#, Capaldo BD#, Vaillant F, Mouchemore KA, Pal B, Chen Y, Surgenor E, Murphy AJ, Anderson RL, Smyth GK, Lindeman GJ, Hawkins ED*, Visvader JE* (2021). Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis. Nature Communications 12(1), 6920. [PubMed] (Accepted 27 Sep 2021, Published 26 Nov 2021)
• Peters TJ, Buckley MJ, Chen Y, Smyth GK, Goodnow CC, Clark SJ (2021). Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate. Nucleic Acids Research 49(19), e109. [PubMed] (Accepted 13 Jul 2021, Epub 28 Jul 2021, Published 8 Nov 2021)
• Grant ZL, Hickey PF, Abeysekera W, Whitehead L, Lewis SM, Symons RCA, Baldwin TM, Amann-Zalcenstein D, Garnham AL, Naik SH, Smyth GK, Thomas T, Voss AK, Coultas L (2021). The histone acetyltransferase HBO1 (KAT7) promotes efficient tip cell sprouting during angiogenesis. Development 148(20), dev199581. [PubMed, Correction PubMed] (Accepted 15 Sep 2021, Epub 22 Sep 2021, Published 26 Oct 2021)
• Zhan Y, Zhang Y, Zhang S, Coughlan H, Baldoni PL, Jacquelot N, Cao WJH, Preston S, Louis C, Rautela J, Pellegrini M, Wicks IP, Alexander WS, Harrison LC, Lew AM, Smyth GK, Nutt SL, Chopin M (2021). Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis. Science Immunology 6(63), eabf7268. [PubMed] (Accepted 18 Aug 2021, Published 17 Sep 2021)
• Roth-Schulze AJ, Penno MAS, Ngui KM, Oakey H, Bandala-Sanchez E, Smith AD, Allnutt TR, Thomson RL, Vuillermin PJ, Craig ME, Rawlinson WD, Davis EA, Harris M, Soldatos G, Colman PG, Wentworth JM, Haynes A, Barry SC, Sinnott RO, Morahan G, Bediaga NG, Smyth GK, Papenfuss AT, Couper JJ, Harrison L (2021). Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome. Microbiome 9(1), 167. [PubMed] (Accepted 14 May 2021, Published 6 Aug 2021)
• Ioannidis LJ, Pietrzak HM, Ly A, Utami RAS, Eriksson EM, Studniberg SI, Abeysekera W, Li-Wai-Suen CSN, Sheerin D, Healer J, Puspitasari AM, Apriyanti D, Coutrier F, Poespoprodjo JR, Kenangalem E, Prayoga A, Sariyanti N, Smyth GK, Trianty L, Cowman AF, Price RN, Noviyanti R, Hansen DS (2021). High dimensional mass cytometry identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malaria. JCI Insight 6(14), 148086. [PubMed] (Accepted 25 May 2021, Epub 15 Jun 2021, Published 22 Jul 2021)
• Pal B#, Chen Y#, Milevskiy MJG#, Vaillant F, Prokopuk L, Dawson C, Capaldo BD, Song X, Jackling F, Timpson P, Lindeman GJ, Smyth GK*, Visvader JE* (2021). Single cell transcriptome atlas of mouse mammary epithelial cells across development. Breast Cancer Research 23(1), 69. [PubMed] (Accepted 28 May 2021, Published 29 Jun 2021)
• Pal B#, Chen Y#, Vaillant F#, Capaldo BD, Joyce R, Song X, Bryant VL, Penington JS, Di Stefano L, Ribera NT, Wilcox S, Mann GB, kConFab, Papenfuss AT, Lindeman GJ, Smyth GK*, Visvader JE* (2021). A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast. EMBO Journal 40(11), e3107333. [PubMed] (Accepted 17 Mar 2021, Epub 5 May 2021, Published 1 Jun 2021)
• Doerflinger M, Haeusler GM, Li-Wai-Suen CSN, Clark JE, Slavin MA, Babl FE, Allaway Z, Mechinaud F, Smyth GK, De Abreu Lourenco R, Phillips B, Pellegrini M, Thursky KA (2021). Procalcitonin and Interleukin-10 may assist in early prediction of bacteraemia in children with cancer and febrile neutropenia. Frontiers in Immunology 12, 641879. [PubMed] (Accepted 27 Apr 2021, Published 20 May 2021)
• Hogg SJ, Motorna O, Cluse LA, Johanson TM, Coughlan HD, Raviram R, Myers RM, Costacurta M, Todorovski I, Pijpers L, Bjelosevic S, Williams T, Huskins SN, Kearney CJ, Devlin JR, Jabbari JS, Martin BP, Fareh M, Kelly MJ, Dupere-Richer D, Sandow JJ, Feran B, Knight D, Khong T, Spencer A, Harrison SJ, Gregory G, Wickramasinghe VO, Webb AI, Taberlay PC, Bromberg KD, Lai A, Papenfuss AT, Smyth GK, Allan RS, Licht JD, Landau DA, Abdel-Wahab O, Shortt J, Vervoort SJ, Johnstone RW (2021). Targeting P300/CBP reveals discrete regulation of transcription and chromatin accessibility by histone acetylation. Molecular Cell 81(10), 2183-2200.e13. [PubMed] (Accepted 26 Mar 2021, Published 20 May 2021)
• Foers AD, Garnham AL, Chatfield S, Smyth GK, Cheng L, Hill AF, Wicks IP, Pang KC (2021). Extracellular vesicles in synovial fluid from rheumatoid arthritis patients contain miRNAs with capacity to modulate inflammation. International Journal of Molecular Sciences 22(9), 4910. [PubMed] (Accepted 5 May 2021, Published 6 May 2021)
• Zhang S, Coughlan HD, Ashayeripanah M, Seizova S, Kueh AJ, Brown DV, Cao W, Jacquelot N, D'Amico A, Lew AM, Zhan T, Tonkin CJ, Villadangos JA, Smyth GK, Chopin M, Nutt SL (2021). Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT. Science Immunology 6(58), eabf4432. [PubMed] (Accepted 3 Mar 2021, Published 2 Apr 2021)
• Keenan CR, Mlodzianoski MJ, Coughlan HD, Bediaga NG, Naselli G, Lucas EC, Wang Q, de Graaf CA, Hilton DJ, Harrison LC, Smyth GK, Rogers KL, Boudier T, Allan RS, Johanson TM (2021). Chromosomes distribute randomly to, but not within, human neutrophil nuclear lobes. iScience 24(3), 102161. [PubMed] (Accepted 3 Feb 2021, Epub 6 Feb 2021, Published 19 Mar 2021)
• Chan WF, Coughlan HD, Iannarella N, Smyth GK, Johanson TM, Keenan CR, Allan RS (2021). Identification and characterization of the long non-coding RNA Dreg1 as a novel regulator of Gata3. Immunology and Cell Biology 99(3), 323-332. [PubMed] (Accepted 23 Sep 2020, Epub 24 Sep 2020, Published 1 Mar 2021)
• Chan WF#, Coughlan HD#, Zhou JHS, Keenan CR, Bediaga N, Hodgkin PD, Smyth GK*, Johanson TM*, Allan RS* (2021). Pre-mitotic genome re-organisation bookends the B cell differentiation process. Nature Communications 12(1), 1344. [PubMed] (Accepted 2 Feb 2021, Published 26 Feb 2021)
• Bediaga NG, Coughlan HD, Johanson TM, Garnham AL, Naselli G, Schröder J, Fearnley LG, Bandala-Sanchez E, Allan RS, Smyth GK, Harrison LC (2021). Multi-level remodelling of chromatin underlying activation of human T cells. Scientific Reports 11(1), 528. [PubMed] (Accepted 15 Dec 2020, Published 12 Jan 2021)

2020

• Law CW, Zeglinski K, Dong X, Alhamdoosh M, Smyth GK*, Ritchie ME* (2020). A guide to creating design matrices for gene expression experiments. F1000Research 9, 1444. [PubMed] [Full Text] [Workflow version] (Accepted 26 Nov 2020, Published 10 Dec 2020)
• Foers AD, Garnham AL, Smyth GK, Proudman SM, Cheng L, Hill AF, Pang KC, Wicks IP (2020). Circulating small non-coding RNA biomarkers of response to triple disease-modifying antirheumatic drug therapy in white women with early rheumatoid arthritis. Journal of Rheumatology 47(12), 1746-1751. [PubMed] (Accepted 5 May 2020, Epub 15 Jun 2020, Published 1 Dec 2020)
• Tong L, Wu PY, Phan JH, Hassazadeh HR, Jones WD, Shi L, Fischer M, Mason CE, Li S, Xu J, Shi W, Wang J, Thierry-Mieg J, Thierry-Mieg D, Hertwig F, Berthold F, Hero B, Liao Y, Smyth GK, Kreil D, Labaj PP, Megherbi D, Schroth G, Fang H, Tong W, Wang MD (2020). Impact of RNA-seq data analysis algorithms on gene expression estimation and downstream prediction. Scientific Reports 10(1), 17925. [PubMed] (Accepted 27 Aug 2020, Published 21 Oct 2020)
• Lalaoui N, Merino D, Giner G, Vaillant F, Chau D, Liu L, Pal B, Whittle JR, Etemadi N, Berthelet J, Gräsel J, Hall C, Ritchie ME, Ernst M, Smyth GK, Vaux DL, Visvader JE, Lindeman GJ, Silke J, Kratina T (2020). Targeting triple negative breast cancers with the Smac-mimetic birinapant. Cell Death and Differentiation 27(10):2768-2780. [PubMed] (Accepted 27 Mar 2020, Epub 27 Apr 2020, Published 1 Oct 2020)
• Keenan CR#, Coughlan HD#, Iannarella N, Johanson TM, Chan WF, Garnham AL, Smyth GK*, Allan RS* (2020). Suv39h-catalysed H3K9me3 is critical for euchromatic genome organisation and the maintenance of gene transcription. bioRxiv 2020.08.13.249078. [DOI] (Published 14 Aug 2020)
• Whittle JR, Vaillant F, Surgenor E, Policheni AN, Giner G, Capaldo BD, Chen H-R, Liu HK, Dekkers JF, Sachs N, Clevers H, Fellowes A, Green T, Xu H, Fox S, Herold MJ, Smyth GK, Gray DHD, Visvader JE, Lindeman GJ (2020). Dual targeting of CDK4/6 and BCL2 pathways in estrogen receptor positive breast cancer. Clinical Cancer Research 26(15), 4120-4134. [PubMed] (Accepted 20 Mar 2020, Epub 3 Apr 2020, Published 1 Aug 2020)
• Ng AP, Coughlan HD, Hediyeh-zadeh S, Behrens K, Johanson TM, Low MSY, Bell CC, Gilan O, Chan YC, Kueh AJ, Boudier T, Feltham R, Gabrielyan A, DiRago L, Hyland CD, Ierino H, Mifsud S, Viney E, Willson T, Dawson MA, Allan RS, Herold MJ, Rogers K, Tarlinton DM, Smyth GK, Davis MJ, Nutt SL, Alexander WS (2020). An Erg-driven transcriptional program controls B-lymphopoiesis. Nature Communications 11(1), 3013. [PubMed] (Accepted 13 Apr 2020, Published 15 Jun 2020)
• Dawson CA, Pal B, Vaillant F, Gandolfo LC, Liu Z, Bleriot C, Ginhoux F, Smyth GK, Lindeman GJ, Mueller SN, Rios AC, Visvader JE (2020). Tissue-resident ductal macrophages survey the mammary epithelium and facilitate gland remodelling during involution. Nature Cell Biology 22(5), 546-558. [PubMed] (Accepted 6 Mar 2020, Epub 27 Apr 2020, Published 1 May 2020)
• Chappaz S, Law CW, Dowling M, Carey KT, Lane RM, Ngo LH, Wickramasinghe VO, Smyth GK, Ritchie ME, Kile BT (2020). Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice. Blood Advances 4(7), 1270-1283. [PubMed] (Accepted 29 Feb 2020, Published 14 Apr 2020)
• Roth-Schulze AJ, Penno MAS, Ngui KM, Oakey H, Thomson RL, Vuillermin PJ, Craig ME, Rawlinson WD, Davis EA, Harris M, Soldatos G, Colman PG, Wentworth JM, Haynes A, Morahan G, Bediaga NG, Smyth GK, Papenfuss AT, Couper JJ, Harrison L (2020). Changes in the composition and function of the gut microbiome accompany type 1 diabetes in pregnancy. Research Square. [DOI] PPR:PPR121947. (Preprint 24 Mar 2020)
• Seillet C, Luong K, Tellier J, Jacquelot N, Shen RD, Hickey P, Wimmer VC, Whitehead L, Rogers K, Smyth GK, Garnham AL, Ritchie ME, Belz GT (2020). The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity. Nature Immunology 21(2), 168-177. [PubMed] (Accepted 19 Oct 2019, Epub 23 Dec 2019, Published 1 Feb 2020)
• Kueh AJ, Eccles S, Tang L, Garnham AL, May RE, Herold MJ, Smyth GK, Voss AK, Thomas T (2020). HBO1 (KAT7) does not have an essential role in cell proliferation, DNA replication, or histone 4 acetylation in human cells. Molecular and Cellular Biology 40(4), e00506-e00519. [PubMed] (Accepted 11 Nov 2019, Epub 25 Nov 2019, Published 30 Jan 2020)
• Sidwell T, Liao Y, Garnham AL, Vasanthakumar A, Gloury R, Blume J, Teh PP, Chisanga D, Thelemann C, de Labastida Rivera F, Engwerda CR, Corcoran L, Kometani K, Kurosaki T, Smyth GK, Shi W, Kallies A (2020). Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis. Nature Communications 11(1), 252. [PubMed] (Accepted 7 Nov 2019, Published 14 Jan 2020)

2019

• Koçhan N, Tutuncu GY, Smyth GK, Gandolfo LC, Giner G (2019). qtQDA: quantile transformed quadratic discriminant analysis for high-dimensional RNA-seq data. PeerJ 7, e8260. [PubMed] [DOI] (Accepted 20 Nov 2019, Published 18 Dec 2019)
• Bhuva DD, Cursons J, Smyth GK, Davis MJ (2019). Differential co-expression based detection of conditional relationships in transcriptional data: comparative analysis and application to breast cancer. Genome Biology 20(1), 236. [PubMed] (Accepted 2 Oct 2019, Published 14 Nov 2019)
• Vrahnas C, Blank M, Dite TA, Tatarczuch L, Ansari N, Crimeen-Irwin B, Nguyen H, Forwood MR, Hu Y, Ikegame M, Bambery KR, Petibois C, Mackie EJ, Tobin MJ, Smyth GK, Oakhill JS, Martin TJ, Sims NA (2019). Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone. Nature Communications 10(1), 3436. [PubMed] (Accepted 3 Jul 2019, Published 31 Jul 2019)
• Vanyai HK, Garnham AL, May RE, McRae HM, Collin C, Wilcox S, Smyth GK, Thomas T, Voss AK (2019). MOZ directs the distal-less homeobox gene expression program during craniofacial development. Development 146(14) dev175042. [PubMed] (Accepted 17 Jun 2019, Epub 24 Jul 2019)
• Stock AT, Collins N, Smyth GK, Hu Y, Hansen JA, D'Silva DB, Jama H, Lew AM, Gebhardt T, Wicks IP (2019). The selective expansion and targeted accumulation of bone-marrow derived macrophages drives cardiac vasculitis. Journal of Immunology 202(11), 3282-3296. [PubMed] (Accepted 29 Mar 2019, Epub 19 Apr 2019, Published 1 Jun 2019)
• Liao Y, Smyth GK, Shi W (2019). The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads. Nucleic Acids Research 47(8), e47. [PubMed] (Accepted 12 Feb 2019, Epub 20 Feb 2019, Published 7 May 2019)
• McRae HM, Garnham AL, Hu Y, Witkowski MT, Corbett MA, Dixon MP, May RE, Sheikh BN, Chiang W, Kueh AJ, Nguyen TA, Man K, Gloury R, Aubrey BJ, Policheni A, Di Rago L, Alexander WS, Gray DHD, Strasser A, Hawkins ED, Wilcox S, Gécz J, Kallies A, McCormack MP, Smyth GK, Voss AK, Thomas T (2019). PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia. Blood 133(16), 1729-1741. [PubMed] (Accepted 23 Jan 2019, Epub 12 Feb 2019, Published 18 Apr 2019)
• Rios AC, Capaldo BD, Vaillant F, Pal B, van Ineveld R, Dawson CA, Chen Y, Nolan E, Fu NY, 3DTCLSM Group, Jackling FC, Devi S, Clouston D, Whitehead L, Smyth GK, Mueller SN, Lindeman GJ, Visvader JE (2019). Intraclonal plasticity in mammary tumors revealed through large-scale single-cell resolution 3D imaging. Cancer Cell 35(4), 618-632. [PubMed] (Accepted 27 Feb 2019, Epub 28 Mar 2019, Published 15 Apr 2019)
• Delbridge ARD, Kueh AJ, Ke F, Zamudio NM, El-Saffin F, Jansz N, Wang G-Y, Iminitoff M, Beck T, Haupt S, Hu Y, May RE, Whitehead L, Tai L, Chiang W, Herold MJ, Haupt Y, Smyth GK, Blewitt ME, Thomas T, Strasser A, Voss AK (2019). Loss of p53 causes stochastic aberrant X-chromosome inactivation and female-specific neural tube defects. Cell Reports 27(2), 442-454. [PubMed] (Accepted 26 Feb 2019, Published 9 Apr 2019)
• Lok SW, Whittle JR, Vaillant F, Teh CE, Lo LL, Policheni AN, Bergin ART, Desai J, Ftouni S, Gandolfo LC, Liew D, Liu HK, Mann GB, Moodie K, Murugasu A, Pal B, Roberts AW, Rosenthal MA, Shackleton K, Silva MJ, Siow ZR, Smyth GK, Taylor L, Travers A, Yeo B, Yeung M, Bujak AZ, Dawson SJ, Gray DHD, Visvader JE, Lindeman GJ (2019). A phase 1b dose-escalation and expansion study of the BCL-2 inhibitor venetoclax combined with tamoxifen in ER and BCL-2-positive metastatic breast cancer. Cancer Discovery 9(3), 354-369. [PubMed] (Accepted 4 Nov 2018, Epub 5 Dec 2018, Published 1 Mar 2019)
• Merino D, Weber TS, Serrano A, Vaillant F, Liu K, Pal B, di Stefano L, Schroeder J, Lin D, Chen Y, Asselin-Labat ML, Schumacher TN, Cameron D, Smyth GK, Papenfuss AT, Lindeman GJ, Visvader JE, Naik SH (2019). Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer. Nature Communications 10(1), 766. [PubMed] (Accepted 18 Jan 2019, Published 15 Feb 2019)
• Bediaga NG, Coughlan HD, Johanson TM, Garnham AL, Naselli G, Schroeder J, Fearnley LG, Bandala-Sanchez E, Smyth GK, Allan RS, Harrison L (2019). Multi-Level Chromosome Remodeling Underlying Activation of Human T Cells. Cell Press Sneak Peek doi: 10.2139/ssrn.3329249. (Posted 5 Feb 2019)
• Chopin M, Lun ATL, Zhan Y, Schreuder J, Coughlan HD, D'Amico A, Mielke LA, Almeida FF, Kueh AJ, Dickins RA, Belz GT, Naik SH, Lew AM, Bouillet P, Herold MJ, Smyth GK, Corcoran LM, Nutt SL (2019). Transcription factor PU.1 promotes conventional dendritic cell identity and function via induction of transcriptional regulator DC-SCRIPT. Immunity 50(1), 77-90. [PubMed] (Accepted 9 Oct 2018, Epub 2 Jan 2019, Published 15 Jan 2019)

2018

• Kim ML, Martin WJ, Minigo G, Keeble JL, Garnham AL, Pacini G, Smyth GK, Speed TP, Carapetis J, Wicks IP (2018). A dysregulated IL-1beta-GM-CSF axis in acute rheumatic fever that is limited by hydroxychloroquine. Circulation 138(23), 2648-2661. [PubMed] (Accepted 27 Jul 2018, Published 4 Dec 2018)
• Fu NY, Pal B, Chen Y, Jackling F, Milevskiy M, Vaillant F, Capaldo B, Guo F, Liu KH, Rios AC, Lim NL, Kueh AJ, Virshup DM, Herold MJ, Tucker HO, Smyth GK, Lindeman GJ, Visvader JE (2018). Foxp1 is indispensable for ductal morphogenesis and controlling the exit of mammary stem cells from quiescence. Developmental Cell 47(5), 629-644. [PubMed] (Accepted 1 Oct 2018, Epub 25 Oct 2018, Published 3 Dec 2018)
• Dunn PK, Smyth GK (2018). Generalized linear models with examples in R. Springer, New York, NY. [DOI] ISBN: 978-1-4419-0118-7. (Accepted 16 Dec 2017, Published 17 Nov 2018)
• Aw WC, Towarnicki SG, Melvin RG, Youngson NA, Garvin MR, Hu Y, Nielsen S, Thomas T, Pickford R, Bustamante S, Vila-Sanjurjo A, Smyth GK, Ballard JWO (2018). Genotype to phenotype: diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness. PLOS Genetics 14(11), e1007735. [PubMed] (Accepted 2 Oct 2018, Published 6 Nov 2018)
• Aubrey BJ, Janic A, Chen Y, Chang C, Lieschke EC, Diepstraten ST, Kueh AJ, Bernardini JP, Dewson G, O'Reilly LA, Whitehead L, Voss AK, Smyth GK, Strasser A, Kelly GL (2018). Mutant TRP53 exerts a target gene selective dominant negative effect to drive tumor development. Genes and Development 32(21-22), 1420-1429. [PubMed] (Accepted 20 Sep 2018, Epub 26 Oct 2018, Published 1 Nov 2018)
• Johanson TM, Lun ATL, Coughlan HD, Tan T, Smyth GK, Nutt SL, Allan RS (2018). Transcription factor-mediated supervision of global genome architecture maintains B cell identity. Nature Immunology 19(11), 1257-1264. [PubMed] (Accepted 5 Sep 2018, Epub 15 Oct 2018, Published 1 Nov 2018)
• Michalak EM, Milevskiy MJG, Joyce RM, Dekkers JF, Jamieson PR, Pal B, Dawson CA, Hu Y, Orkin SH, Alexander WS, Lindeman GJ, Smyth GK, Visvader JE (2018). Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids. PLOS Biology 16(8), e2004986. [PubMed] (Accepted 26 Jul 2018, Published 6 Aug 2018)
• Baell JB, Leaver DJ, Hermans SJ, Kelly GL, Brennan MS, Downer NL, Nguyen N, Wichmann J, McRae HM, Yang Y, Cleary B, Lagiakos HR, Mieruszynski S, Pacini G, Vanyai HK, Bergamasco MI, May RE, Davey BK, Morgan KJ, Sealey AJ, Wang B, Zamudio N, Wilcox S, Garnham AL, Sheikh BN, Aubrey BJ, Doggett K, Chung MC, de Silva M, Bentley J, Pilling P, Hattarki M, Dolezal O, Dennis M, Falk H, Ren B, Charman SA, White KL, Rautela J, Newbold A, Hawkins ED, Johnstone RW, Huntington ND, Peat TS, Heath JK, Strasser A, Parker MW, Smyth GK, Street IP, Monahan BJ, Voss AK, Thomas T (2018). Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumor growth. Nature 560(7717), 253-257. [PubMed] (Accepted 21 Jun 2018, Published 1 Aug 2018)
• Johanson TM#, Coughlan HD#, Lun ATL, Bediaga NG, Naselli G, Garnham AL, Harrison LC, Smyth GK, Allan RS (2018). Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development. PLOS Genetics 14(6), e1007431. [PubMed] (Accepted 18 May 2018, Published 8 Jun 2018)
• O'Reilly LA, Putoczki TL, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A (2018). Loss of NF-kB1 function causes gastric cancer by deregulating STAT1 dependent control of inflammation and immune checkpoints. Immunity 48(3), 570-583. [PubMed] (Accepted 18 Jan 2018, Published 20 Mar 2018)
• Xin A#, Lee M#, Hu Y#, Ignjatovic V, Shi W, Shipp A, Praporski S, Kallies A, Weintraub R, Monagle P, Smyth GK*, Konstantinov I* (2018). Identifying low-grade cellular rejection after heart transplantation in children using gene expression profiling. Physiological Genomics 50(3), 190-196. [PubMed] (Accepted 8 Dec 2017, Epub 20 Dec 2017, Published 1 Mar 2018)
• Vrahnas C, Dite TA, Ansari N, Crimeen-Irwin B, Nguyen H, Forwood MR, Hu Y, Ikegame M, Bambery KR, Petibois C, Tobin MJ, Smyth GK, Oakhill JS, Martin TJ, Sims NA (2018). Increased autophagy in ephrinB2 deficient osteocytes is associated with hypermineralized, brittle bones. bioRxiv. [DOI] (Preprint 5 Feb 2018, revised 1 Mar 2018)

2017

• Jain R, Sheridan JM, Policheni A, Heinlein M, Gandolfo LC, Dewson G, Smyth GK, Sansom SN, Fu NY, Visvader JE, Holländer GA, Strasser A, Gray DHD (2017). A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice. Blood 130(23), 2504-2515. [PubMed] (Accepted 22 Sep 2017, Epub 29 Sep 2017, Published 7 Dec 2017)
• Wentworth J, Zhang J-G, Bandala-Sanchez E, Naselli G, Liu R, Ritchie ME, Smyth GK, O'Brien PE, Harrison LC (2017). Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin release. International Journal of Obesity 41(12), 1782-1789. [PubMed] (Accepted 17 Jul 2017, Epub 3 Aug 2017, Published 1 Dec 2017)
• Chen Y, Pal B, Visvader JE, Smyth GK (2017). Differential methylation analysis of reduced representation bisulfite sequencing experiments using edgeR. F1000Research 6, 2055. [PubMed] [Corrected preprint, code and data] (Published 28 Nov 2017, Version 2 published 8 Oct 2018)
• Pal B#, Chen Y#, Vaillant F#, Jamieson P, Gordon L, Rios AC, Wilcox S, Fu N, Liu KH, Jackling FC, Davis MJ, Lindeman GJ, Smyth GK*, Visvader JE* (2017). Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling. Nature Communications 8(1), 1627. [PubMed] (Accepted 28 Sep 2017, Published 20 Nov 2017)
• Johanson TM#, Coughlan HD#, Lun ATL, Bediaga NG, Naselli G, Garnham AL, Harrison LC, Smyth GK, Allan RS (2017). No kissing in the nucleus: unbiased analysis reveals no evidence of trans chromosomal regulation of mammalian immune development. bioRxiv. [DOI] (Epub 2 Nov 2017)
• Williams SP, Odell AF, Karnezis T, Farnsworth RH, Gould CM, Li J, Paquet-Fifield S, Harris NC, Walter A, Gregory JL, Lamont SF, Liu R, Takano EA, Nowell CJ, Bower NI, Resnick D, Smyth GK, Coultas L, Hogan BM, Fox SB, Mueller SN, Simpson KJ, Achen MG, Stacker SA (2017). Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling. Science Signaling 10(499), eaal2987. [PubMed] (Accepted 15 Aug 2017, Published 3 Oct 2017)
• Kueh AJ, Pal M, Tai L, Liao Y, Smyth GK, Shi W, Herold MJ (2017). An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles. Cell Death and Differentiation 24(10), 1821-1822. [PubMed] (Accepted 19 Jun 2017, Epub 28 Jul 2017, Published 1 Oct 2017)
• Nguyen TA, Smith BRC, Tate MD, Belz GT, Barrios MH, Elgass KD, Weisman AS, Baker PJ, Preston S, Whitehead L, Garnham AL, Lundie RJ, Smyth GK, Pellegrini M, O'Keeffe M, Wicks IP, Masters SL, Hunter CP, Pang KC (2017). SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition. Immunity 47(3), 498-509. [PubMed] (Accepted 31 Jul 2017, Epub 12 September 017, Published 19 Sep 2017)
• Vasanthakumar A, Liao Y, Teh P, Pascutti MF, Oja AE, Garnham AL, Gloury R, Tempany JC, Sidwell T, Cuadrado E, Tuijnenburg P, Kuijpers TW, Lalaoui N, Mielke LA, Bryant VL, Hodgkin PD, Silke J, Smyth GK, Nolte MA, Shi W, Kallies A. (2017). The TNF receptor superfamily-NF-κB axis is critical to maintain effector regulatory T cells in lymphoid and non-lymphoid tissues. Cell Reports 20(12), 2906-2920. [PubMed] (Epub 7 Sep 2017, Published 19 Sep 2017)
• Merino D, Whittle JR, Vaillant F, Serrano A, Gong J-N, Giner G, Maragno AL, Chanrion M, Schneider E, Pal B, Li X, Dewson G, Gräsel J, Liu K, Lalaoui N, Segal D, Herold MJ, Huang DCS, Smyth GK, Geneste O, Lessene G, Visvader JE, Lindeman GJ (2017). Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple negative and HER2-amplified breast cancer. Science Translational Medicine 9(401), eaam7049. [PubMed] (Accepted 29 Jun 2017, Published 2 Aug 2017)
• Lun ATL, Smyth GK (2017). No counts, no variance: allowing for loss of degrees of freedom when assessing biological variability from RNA-seq data. Statistical Applications in Genetics and Molecular Biology 16(2), 83-93. [PubMed] [Preprint] (Accepted 26 Apr 2017, Published 25 May 2017)
• Piovesan D, Tempany J, Di Pietro A, Baas I, Yiannis C, O'Donnell K, Chen Y, Peperzak V, Belz GT, Mackay CR, Smyth GK, Groom JR, Tarlinton DM, Good-Jacobson KL (2017). c-Myb regulates the T-bet-dependent differentiation program in B cells to coordinate antibody responses. Cell Reports 19(3), 461-470. [PubMed] (Accepted 6 Mar 2017, Published 18 Apr 2017)
• Vasanthakumar A, Xu D, Lun ATL, Kueh AJ, van Gisbergen KPJM, Iannarella N, Li X, Yu L, Wang D, Williams BRG, Lee SCW, Majewski IJ, Godfrey DI, Smyth GK, Alexander WS, Herold MJ, Kallies A, Nutt SL, Allan RS (2017). A non-canonical function for Ezh2 in the preservation of immune homeostasis. EMBO Reports 18(4), 619-631. [PubMed] (Accepted 23 Jan 2017, Epub 21 Feb 2017, Published 1 Apr 2017)
• Holik AZ#, Law CW#, Liu R, Wang Z, Wang W, Ahn J, Marie-Liesse A-L, Smyth GK, Ritchie ME (2017). RNA-seq mixology: designing realistic control experiments to compare protocols and analysis methods. Nucleic Acids Research 45(5), e30. [PubMed] (Accepted 19 Oct 2016, Epub 29 Nov 2016, Published 17 Mar 2017)
• Witkowski MT, Hu Y, Roberts KG, Boer JM, McKenzie MD, Liu GJ, Le Grice OD, Tremblay CS, Ghisi M, Willson TA, Horstmann MA, Aifantis I, Cimmino L, Frietze S, den Boer ML, Mullighan CG, Smyth GK, Dickins RA (2017). Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome. Journal of Experimental Medicine 214(3), 773-791. [PubMed] (Accepted 22 Nov 2016, Epub 10 Feb 2017, Published 6 Mar 2017)
• Fu NY, Rios AC, Pal B, Law CW, Jamieson P, Liu R, Vaillant F, Jackling F, Liu KH, Smyth GK, Lindeman GJ, Ritchie ME, Visvader JE (2017). Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive. Nature Cell Biology 19(3), 164-176. [PubMed] (Accepted 11 Jan 2017, Epub 13 Feb 2017, Published 1 Mar 2017)
• Weeden CE, Chen Y, Ma SB, Hu Y, Ramm G, Sutherland KD, Smyth GK, Asselin-Labat ML (2017). Lung basal stem cells rapidly repair DNA damage using the error-prone non-homologous end-joining pathway. PLOS Biology 15(1), e2000731. [PubMed] (Accepted 23 Dec 2016, Published 26 Jan 2017)
• Dias S, D'Amico A, Cretney E, Liao Y, Tellier J, Bruggeman CW, Almeida FF, Leahy J, Belz GT, Smyth GK, Shi W, Nutt SL (2017). Effector regulatory T cell differentiation and immune homeostasis depend on the transcription factor Myb. Immunity 46(1), 78-91. [PubMed] (Accepted 23 Nov 2016, Published 17 Jan 2017)
• Gregory JL, Walter A, Alexandre YO, Hor JL, Liu R, Ma J, Devi S, Tokuda N, Owada Y, Mackay LK, Smyth GK, Heath WR, Mueller SN (2017). Infection programs sustained lymphoid stromal cell responses and shapes lymph node remodeling upon secondary challenge. Cell Reports 18(2), 406-418. [PubMed] (Accepted 12 Dec 2016, Published 10 Jan 2017)

2016

• Teh C, Lalaoui N, Jain R, Policheni A, Heinlein M, Alvarez-Diaz S, Sheridan J, Rieser E, Deuser S, Darding M, Koay HF, Hu Y, Kupresanin F, O'Reilly L, Godfrey D, Smyth GK, Bouillet P, Strasser A, Walczak H, Silke J, Gray D (2016). The linear ubiquitin chain assembly complex coordinates late thymic T cell differentiation and regulatory T cell homeostasis. Nature Communications 7, 13353. [PubMed] (Accepted 26 Sep 2016, Published 18 Nov 2016)
• Walker EC, Johnson RW, Hu Y, Brennan HJ, Poulton IJ, Zhang J-G, Jenkins BJ, Smyth GK, Nicola NA, Sims NA (2016). Murine Oncostatin M acts via Leukemia Inhibitory Factor Receptor to phosphorylate STAT3 but not STAT1, an effect that protects bone mass. Journal of Biological Chemistry 291(41), 21703-21716. [PubMed] (Accepted 17 Aug 2016, Epub 18 Aug 2016, Published 7 Oct 2016)
• Newman DM, Sakaguchi S, Lun ATL, Preston S, Pellegrini M, Khamina K, Bergthaler A, Nutt SL, Smyth GK, Voss AK, Thomas T, Ellmeier W, Belz GT, Allan RS (2016). Acetylation of the Cd8 locus by KAT6A determines memory T cell diversity. Cell Reports 16(12), 3311-3321. [PubMed] (Accepted 18 Aug 2016, Published 20 Sep 2016)
• de Graaf CA, Choi J, Baldwin TM, Bolden JE, Fairfax KA, Robinson AJ, Biben C, Morgan C, Ramsay K, Ng AP, Kauppi M, Kruse EA, Sargeant TJ, Seidenman N, D'Amico A, D'Ombrain MC, Lucas EC, Koernig S, Morelli AB, Wilson MJ, Dower SK, Williams B, Heazlewood SY, Hu Y, Nilsson SK, Wu L, Smyth GK, Alexander WS, Hilton DJ (2016). Haemopedia: an expression atlas of murine hematopoietic cells. Stem Cell Reports 7(3), 571-582. [PubMed] (Accepted 10 Jul 2016, Epub 4 Aug 2016, Published 13 Sep 2016)
• Giner G, Smyth GK (2016). statmod: probability calculations for the inverse Gaussian distribution. The R Journal 8(1), 339-351. [DOI] [arXiv preprint] (Accepted 28 Apr 2016, Published 31 Aug 2016)
• Nolan E, Vaillant F, Branstetter D, Pal B, Giner G, Whitehead L, Lok SW, Mann GB, kConFab, Rohrbach K, Huang LY, Soriano R, Smyth GK, Dougall WC, Visvader JE, Lindeman GJ (2016). RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers. Nature Medicine 22(8), 933-939. [PubMed] (Accepted 6 May 2016, Epub 20 Jun 2016, Published 1 Aug 2016)
• Phipson B, Lee S, Majewski IJ, Alexander WS, Smyth GK (2016). Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression. Annals of Applied Statistics 10, 946-963. [DOI] [PubMed] [arXiv preprint] (Accepted 25 Feb 2016, Published 31 Jun 2016)
• Chen Y, Lun ATL, Smyth GK (2016). From reads to genes to pathways: differential expression analysis of RNA-Seq experiments using Rsubread and the edgeR quasi-likelihood pipeline. F1000Research 5, 1438. [PubMed] [Full text] [Preprint PDF] [Data and R code] (Published 20 Jun 2016)
• Law CW, Alhamdoosh M, Su S, Dong X, Tian L, Smyth GK*, Ritchie ME* (2016). RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR. F1000Research 5, 1408. [PubMed] [Full text] (Published 17 Jun 2016, Revised 1 Jan 2017 and 28 Dec 2018)
• Taberlay PC, Achinger-Kawecka J, Lun ATL, Buske FA, Sabir K, Gould CM, Zotenko E, Bert SA, Giles KA, Bauer DC, Smyth GK, Stirzaker C, O'Donoghue SI, Clark SJ (2016). Three-dimensional disorganisation of the cancer genome occurs coincident with long-range genetic and epigenetic alterations. Genome Research 26(6), 719-731. [PubMed] (Accepted 5 Apr 2016, Epub 6 Apr 2016, Published 1 Jun 2016)
• Chopin M, Preston SP, Lun ATL, Tellier J, Smyth GK, Pellegrini M, Belz GT, Corcoran LM, Visvader JE, Wu L, Nutt SL (2016). RUNX2 mediates plasmacytoid dendritic cell egress from the bone marrow and controls viral immunity. Cell Reports 15, 866-878. [PubMed] (Accepted 3 Mar 2016, Epub 13 April, Published 26 Apr 2016)
• Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, Olshansky M, Lin JX, Li P, Speed TP, Smyth GK, Ernst M, Leonard WJ, Pellegrini M, Kaech SM, Nutt SL, Shi W, Belz GT, Kallies A (2016). A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet. Nature Immunology 17, 422-432. [PubMed] (Accepted 7 Dec 2015, Epub 7 Mar 2016, Published 1 Apr 2016)
• Wentworth JM, Naselli G, Ngui K, Smyth GK, Liu R, O'Brien PE, Bruce C, Weir J, Cinel M, Meikle PJ, Harrison LC (2016). GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women. International Journal of Obesity 40, 706-713. [PubMed] (Epub 26 Oct 2015, Published 1 Apr 2016)
• Lun ATL, Chen Y, Smyth GK (2016). It's DE-licious: a recipe for differential expression analyses of RNA-seq experiments using quasi-likelihood methods in edgeR. Methods in Molecular Biology 1418, 391-416. [PubMed] [Preprint 8 Apr 2015] (Accepted 9 Oct 2015, Published 24 Mar 2016)
• Lun ATL, Smyth GK (2016). csaw: a Bioconductor package for differential binding analysis of ChIP-seq data using sliding windows. Nucleic Acids Research 44, e45. [PubMed] (Accepted 24 Oct 2015, Epub 17 Nov 2015, Published 18 Mar 2016)
• Tellier J, Shi W, Minnich M, Liao Y, Crawford S, Smyth GK, Kallies A, Busslinger M, Nutt SL (2016). Blimp1 controls plasma cell function through regulation of immunoglobulin secretion and the unfolded protein response. Nature Immunology 17, 323-330. [PubMed] (Accepted 30 Sep 2015, Epub 18 Jan 2016, Published 1 Mar 2016)
• Rankin LC, Girard-Madoux MJH, Seillet C, Mielke LA, Kerdiles Y, Fenis A, Wieduwild E, Putoczki T, Mondot S, Lantz O, Demon D, Papenfuss AT, Smyth GK, Lamkanfi M, Carotta S, Renauld J-C, Shi W, Carpentier S, Soos T, Arendt C, Ugolini S, Huntington ND, Belz GT, Vivier E (2015). Complementarity and redundancy of IL-22-producing innate lymphoid cells. Nature Immunology 17, 179-186. [PubMed] (Accepted 16 Oct 2015, Epub 30 Nov 2015, Published 1 Feb 2016)
• Shields BJ, Jackson JT, Metcalf D, Shi W, Huang Q, Garnham AL, Glaser SP, Beck D, Pimanda JE, Bogue CW, Smyth GK, Alexander WS, McCormack MP (2016). Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a. Genes & Development 30, 78-91. [PubMed] (Accepted 24 Nov 2015, Published 1 Jan 2016)

2015

• Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekra W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J (2015). TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine Kinase 1. eLife 4, e10592. [PubMed] (Accepted 21 Dec 2015, Published 23 Dec 2015)
• Sheikh BN, Phipson B, El-Saafin F, Vanyai HK, Downer NL, Bird MJ, Kueh AJ, May RE, Smyth GK, Voss AK, Thomas T (2015). MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway. Oncogene 34, 5807-5820. [PubMed] (Accepted 23 Jan 2015, Epub 16 Mar 2015, Published 19 Nov 2015)
• Coffey MJ, Sleebs BE, Uboldi AD, Garnham AL, Franco M, Marino ND, Panas MW, Ferguson DJP, Enciso M, O'Neill MT, Lopaticki S, Stewart RJ, Dewson G, Smyth GK, Smith BJ, Masters SL, Boothroyd JC, Boddey JA, Tonkin CJ (2015). An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell. eLife 4, e10809. [PubMed] (Accepted 18 Nov 2015, Published 18 Nov 2015)
• Lun ATL, Smyth GK (2015). From reads to regions: a Bioconductor workflow to detect differential binding in ChIP-seq data. F1000Research 4, 1080. doi: 10.12688/f1000research.7016.2. [PubMed] (Published 16 Oct 2015)
• Khong JJ, Wang LY, Smyth GK, McNab AA, Hardy TG, Selva D, Llamas B, Jung C-H, Sharma S, Burdon KP, Ebeling PR, Craig JE (2015). Gene expression profiling of orbital adipose tissue in thyroid orbitopathy. Investigative Ophthalmology & Visual Science 56, 6438-6447. [PubMed] (Accepted 9 Aug 2015, Published 1 Oct 2015)
• Liu X, Liu R, Croker BA, Lawlor KE, Smyth GK, Wicks IP (2015). Distinctive pro-inflammatory gene signatures induced in articular chondrocytes by oncostatin M and IL-6 are regulated by Suppressor of Cytokine Signaling-3. Osteoarthritis and Cartilage 23, 1743-1754. [PubMed] (Accepted 21 May 2015, Epub 2 Jun 2015, Published 1 Oct 2015)
• Liu R, Holik AZ, Su S, Jansz N, Chen K, Leong HS, Blewitt ME, Asselin-Labat M-L, Smyth GK, Ritchie ME (2015). Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses. Nucleic Acids Research 43, e97. [PubMed] (Accepted 17 Apr 2015, Epub 29 Apr 2015, Published 3 Sep 2015)
• Lun ATL, Smyth GK (2015). diffHic: a Bioconductor package to detect differential genomic interactions in Hi-C data. BMC Bioinformatics 16, 258. [PubMed] (Accepted 21 Jul 2015, Published 19 Aug 2015)
• Pal B, Chen Y, Bert A, Hu Y, Beck T, Sheridan JM, Shi W, Satterley K, Jamieson P, Goodall GJ, Lindeman GJ, Smyth GK, Visvader JE (2015). Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits. Breast Cancer Research 17, 85. [PubMed] (Accepted 2 May 2015, Published 18 Jun 2015)
• Shi W, Liao Y, Willis SN, Taubenheim N, Inouye M, Tarlinton DM, Smyth GK, Hodgkin PD, Nutt SL, Corcoran LM (2015). Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells. Nature Immunology 16, 663-673. [PubMed] (Accepted 16 Feb 2015, Epub 20 Apr 2015, Published 1 Jun 2015)
• Witkowski MT, Cimmino L, Hu Y, Trimarchi T, Tagoh H, McKenzie MD, Best SA, Tuohey L, Willson TA, Nutt SL, Meinrad Busslinger M, Aifantis I, Smyth GK, Dickins RA (2015). Activated Notch counteracts Ikaros tumor suppression in mouse and human T cell acute lymphoblastic leukemia. Leukemia 29, 1301-1311. [PubMed] (Accepted 29 Jan 2015, Epub 6 Feb 2015, Published 1 Jun 2015)
• Ng AP, Hu Y, Metcalf D, Hyland CD, Ierino H, Phipson B, Wu D, Baldwin TM, Kauppi M, Kiu H, Di Rago L, Hilton DJ, Smyth GK, Alexander WS (2015). Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model. PLOS Genetics 11, e1005211. [PubMed] (Accepted 14 Apr 2015, Published 14 May 2015)
• Sheikh BN, Downer NL, Phipson B, Vanyai HK, Kueh AJ, McCarthy DJ, Smyth GK, Thomas T, Voss AK (2015). MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo. Proceedings of the National Academy of Sciences of the United States of America 112, 5437-5442. [PubMed] (Accepted 24 Mar 2015, Epub 14 Apr 2015, Published 28 Apr 2015)
• Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK (2015). limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Research 43, e47. [DOI] [Preprint 2 Jan 2015] (Accepted 6 Jan 2015, Epub 20 Jan 2015, Published 20 Apr 2015)
• Sheridan JM, Ritchie ME, Best SA, Jiang K, Beck TJ, Vaillant F, Liu K, Dickins RA, Smyth GK, Lindeman GJ, Visvader JE (2015). A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1. BMC Cancer 15, 221. [PubMed] (Accepted 12 Mar 2015, Published 3 Apr 2015)
• Fu NY, Rios AC, Pal B, Soetanto R, Lun AT, Liu K, Beck T, Best SA, Vaillant F, Bouillet P, Strasser A, Preiss T, Smyth GK, Lindeman GJ, Visvader J (2015). EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival. Nature Cell Biology 17, 365-375. [PubMed] (Accepted 19 Jan 2015, Epub 2 Mar 2015, Published 1 Apr 2015)
• Smyth GK (2015). Optimization and nonlinear equations. Wiley StatsRef: Statistics Reference Online (edited by W. Piegorsch), John Wiley & Sons, [DOI], 9 pages. [Preprint 12 Nov 2014] (Accepted 20 Nov 2014, Published 31 Mar 2015)
• Sheikh BN, Lee SC, El-Saafin F, Vanyai HK, Hu Y, Pang SH, Grabow S, Strasser A, Nutt SL, Alexander WS, Smyth GK, Voss AK, Thomas T (2015). MOZ regulates B cell progenitors in mice and consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development. Blood 125, 1910-1921. [PubMed] (Accepted 12 Jan 2015, Epub 20 Jan 2015, Published 19 Mar 2015)
• Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke L, Afshar-Sterle S, Masters S, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A (2015). The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. Nature Immunology 16, 276-285. [PubMed] (Accepted 8 Dec 2014, Epub 19 Jan 2015, Published 1 Mar 2015)
• Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oles AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M (2015). Orchestrating high-throughput genomic analysis with Bioconductor. Nature Methods 12, 115-121. [PubMed] (Accepted 15 Dec 2014, Epub 29 Jan 2015, Published 1 Feb 2015)
• Overview of the csaw package. Bioconductor Newsletter, January 2015. (Published 5 Jan 2015)

2014

• Shi W, Man K, Smyth GK, Nutt SL, Kallies A (2014). Whole transcriptome analysis for T cell receptor-affinity and IRF4-regulated clonal expansion of T cells. Genomics Data 2, 396-398. [PubMed] (Accepted 28 Oct 2014, Epub 1 Nov 2014, Published 1 Dec 2014)
• Tan K-L, Ling K-H, Hewitt CA, Cheah P-S, Simpson K, Gordon L, Pritchard MA, Smyth GK, Thomas T, Scott HS (2014). Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome. Genomics Data 2, 314-317. [PubMed] (Accepted 23 Sep 2014, Epub 2 Oct 2014, Published 1 Dec 2014)
• Holmes M, Thong R, Brady J, Huntington N, Hayakawa Y, Andoniou C, Fleming P, Degli-Esposti M, Belz G, Kallies A, Carotta S, Smyth M, Shi W, Smyth GK, Nutt S (2014). Peripheral natural killer cell maturation depends on the transcription factor Aiolos. The EMBO Journal 33, 2721-2734. [PubMed] (Accepted 28 Aug 2014, Epub 15 Oct 2014, Published 18 Nov 2014)
• Potts KS, Sargeant TJ, Markham JF, Shi W, Biben C, Josefsson EC, Whitehead LW, Rogers KL, Liakhovitskaia A, Smyth GK, Kile BT, Medvinsky A, Alexander WS, Hilton DJ, Taoudi S (2014). A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo. Blood 124(17), 2725-2729. [PubMed] (Accepted 8 Jul 2014, Epub 25 Jul 2014, Published 23 Oct 2014)
• Smyth GK (2014). Nonlinear regression – extensions. Wiley StatsRef: Statistics Reference Online (edited by W. Piegorsch), John Wiley & Sons, [DOI] (Originally published in Encyclopedia of Environmetrics, republished in Wiley StatsRef 29 Sep 2014.)
• Smyth GK (2014). Polynomial approximation. Wiley StatsRef: Statistics Reference Online (edited by T. Colton), John Wiley & Sons, [DOI] [Preprint] (Originally published in Encyclopedia of Biostatistics, republished in Wiley StatsRef 29 Sep 2014.)
• Smyth GK (2014). Optimization and nonlinear equations. Wiley StatsRef: Statistics Reference Online (edited by T. Colton), John Wiley & Sons, [DOI] (Originally published in Encyclopedia of Biostatistics, republished in Wiley StatsRef 29 Sep 2014.)
• Smyth GK (2014). Numerical integration. Wiley StatsRef: Statistics Reference Online (edited by T. Colton), John Wiley & Sons, doi: 10.1002/9781118445112.stat05029. [DOI] (Originally published in Encyclopedia of Biostatistics, republished in Wiley StatsRef 29 Sep 2014.)
• Smyth GK (2014). Numerical analysis. Wiley StatsRef: Statistics Reference Online (edited by T. Colton), John Wiley & Sons, [DOI] (Originally published in Encyclopedia of Biostatistics, republished in Wiley StatsRef 29 Sep 2014.)
• Maindonald JH, Smyth GK (2014). Matrix computations. Wiley StatsRef: Statistics Reference Online (edited by T. Colton), John Wiley & Sons, [DOI] (Originally published in Encyclopedia of Biostatistics, republished in Wiley StatsRef 29 Sep 2014.)
• Munro SA, Lund SP, Pine PS, Binder H, Clevert D-A, Conesa A, Dopazo J, Fasold M, Hochreiter S, Hong H, Jafari N, Kreil DP, Labaj PP, Li S, Liao Y, Lin SM, Meehan J, Mason CE, Santoyo J, Setterquist RA, Shi L, Shi W, Smyth GK, Stralis-Pavese N, Su Z, Tong W, Wang C, Wang J, Xu J, Ye Z, Yang Y, Yu Y, Salit M (2014). Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures. Nature Communications 5, 5125. [PubMed] (Accepted 14 Aug 2014, Published 25 Sep 2014)
• Su Z, Labaj PP, Li S, Thierry-Mieg J, Thierry-Mieg D, Shi W, Wang C, Schroth GP, Setterquist RA, Thompson JF, Jones WD, Xiao W, Xu W, Jensen RV, Kelly R, Xu J, Conesa A, Furlanello C, Gao H, Hong H, Jafari N, Letovsky S, Liao Y, Lu F, Oakeley EJ, Peng Z, Praul CA, Santoyo-Lopez J, Scherer A, Shi T, Smyth GK, Staedtler F, Sykacek P, Tan X-X, Thompson A, Vandesompele J, Wang MD, Eli JW, Wolfinger RD, Zavadil J, Auerbach SS, Bao W, Binder H, Blomquist T, Brilliant MH, Bushel PR, Cai W, Catalano JG, Chang C-W, Chen T, Chen G, Chen R, Chierici M, Chu T-M, Clevert D-A, Deng Y, Derti A, Devanara V, Dong Z, Dopazo J, Du T, Fang H, Fang Y, Fasold M, Fernandez A, Fischer M, Furió-Tarí P, Fuscoe JC, Gaj S, Gandara J, Gao H, Ge W, Gondo Y, Gong B, Gong M, Gong Z, Green B, Guo C, Guo L, Guo L-W, Hadfield J, Hellemans J, Hochreiter S, Jia M, Jian M, Johnson CD, Kay S, Kleinjans J, Lababidi S, Levy S, Li Q-Z, Li L, Li P, Li Y, Li H, Li J, Li S, Lin SM, López FJ, Lu X, Luo H, Ma X, Meehan J, Megherbi DB, Mei N, Mu B, Ning B, Pandey A, Pérez-Florido J, Perkins RG, Peters R, Phan JH, Pirooznia M, Qian F, Qing T, Rainbow L, Rocca-Serra P, Sambourg L, Sansone S-A, Schwartz S, Shah R, Shen J, Smith TM, Stegle O, Stralis-Paves N, Stupka E, Suzuki Y, Szkotnicki LT, Tinning M, Tu B, van J, Vela A, Venturini E, Walker SJ, Wan L, Wang W, Wang J, Wang J, Wieben ED, Willey JC, Wu P-Y, Xuan J, Yang Y, Ye Z, Yin Y, Yu Y, Yuan Y-C, Zhang J, Zhang KK, Zhang W, Zhang W, Zhang Y, Zhao C, Zheng Y, Zhou Y, Zumbo P, Tong W, Kreil DP, Mason CE, Shi L (2014). A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nature Biotechnology 32(9), 903-914. [PubMed] (Accepted 11 May 2014, Epub 24 Aug 2014, Published 1 Sep 2014)
• Ling K-H, Hewitt CA, Tan K-L, Cheah P-S Vidyadaran S, Lai M-I, Lee H-C, Simpson K, Hyde L, Pritchard MA, Smyth GK, Thomas T, Scott HS (2014). Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks. BMC Genomics 15, 624. [PubMed] (Accepted 16 Jul 2014, Published 22 Jul 2014)
• Good-Jacobson KL, Chen Y, Voss AK, Smyth GK, Thomas T, Tarlinton DM (2014). Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ. PNAS 111, 9585-9590. [PubMed] (Accepted 28 May 2014, Epub 16 Jun 2014, Published 1 Jul 2014)
• Chen Y, Lun ATL, Smyth GK (2014). Differential expression analysis of complex RNA-seq experiments using edgeR. In: Statistical Analysis of Next Generation Sequence Data, Somnath Datta and Daniel S Nettleton (eds), Springer, New York, pages 51--74. [Publisher] [Preprint 31 Jan 2014] (Accepted 8 Feb 2014, Published 1 Jul 2014)
• Lun ATL, Smyth GK (2014). De novo detection of differentially bound regions for ChIP-seq data using peaks and windows: controlling error rates correctly. Nucleic Acids Research 42, e95. [Publisher] [PubMed] (Accepted 14 Apr 2014, Epub 22 May 2014, Published 17 Jun 2014)
• Liu GJ, Cimmino L, Jude JG, Hu Y, Witkowski MT, McKenzie MD, Kartal-Kaess M, Best SA, Tuohey L, Liao Y, Shi W, Mullighan CG, Farrar MA, Nutt SL, Smyth GK, Zuber J, Dickins RA (2014). Pax5 loss imposes a reversible differentiation block in B progenitor acute lymphoblastic leukemia. Genes & Development 28, 1337-1350. [PubMed] (Accepted 16 May 2014, Published 15 Jun 2014)
• Giner G, Smyth GK (2014). A monotonically convergent Newton iteration for the quantiles of any unimodal distribution, with application to the inverse Gaussian distribution. [Preprint 28 May 2014]
• Chevrier, S, Emslie, D, Shi, W, Kratina, T, Wellard, C, Karnowski, A, Erikci, E, Smyth, GK, Chowdhury, K, Tarlinton, D, and Corcoran, LM (2014). The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity. Journal of Experimental Medicine 211, 827-840. [PubMed] (Accepted 10 Feb 2014, Epub 7 Apr 2014, Published 5 May 2014)
• Willis, SN, Good-Jacobson, KL, Curtis, J, Light, A, Tellier, J, Shi, W, Smyth, GK, Tarlinton, DM, Belz, GT, Corcoran LM, Kallies, A, and Nutt, SL (2014). Transcription factor IRF4 regulates germinal center cell formation through a B-cell intrinsic mechanism. Journal of Immunology 192, 3200-3206. [PubMed] (Accepted 28 Jan 2014, Epub 3 Mar 2014, Published 1 Apr 2014)
• Liao Y, Smyth GK, Shi W (2014). featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30(7), 923-930. [PubMed] (Accepted 7 Nov 2013, Epub 13 Nov 2013, Published 1 Apr 2014)
• Law CW, Chen Y, Shi W, Smyth GK (2014). Voom: precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biology 15, R29. [PubMed] [Supplementary Information] [Preprint with corrections] [F1000Prime review] (Accepted 9 Jan 2014, Published 3 Feb 2014)
• Bryant, PA, Smyth, GK, Gooding, T, Oshlack, A, Harrington, Z, Currie, B, Carapetis, J, Robins-Browne, R, and Curtis, N (2014). Susceptibility to acute rheumatic fever: differential expression of genes involved in cytotoxicity, chemotaxis and apoptosis. Infection and Immunity 82, 753-761. [PubMed] (Accepted 24 Nov 2013, Epub 2 Dec 2013, Published 1 Feb 2014)
• Dagley, LF, White, CA, Liao, Y, Shi, W, Smyth, GK, Orian, JM, Emili, A, and Purcell, AW (2014). Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain. Proteomics 14, 241-261. [PubMed] (Accepted 11 Nov 2013, Epub 20 Nov 2013, Published 1 Feb 2014)

2013

• Pasricha S, Payne M, Canovas D, Pase L, Ngaosuwankul P, Beard S, Oshlack A, Smyth GK, Chaiyaroj SC, Boyce KJ, Andrianopoulos A (2013). Cell type specific transcriptional profiles of the dimorphic pathogen Penicillium marneffei reflect distinct reproductive, morphological and environmental demands. G3: Genes, Genomes, Genetics 3, 1997-2014. [PubMed] [Cover image] (Accepted 6 Sep 2013, Epub 23 Sep 2013, Published 6 Nov 2013)
• Man K, Miasari M, Shi W, Xin A, Henstridge DC, Preston S, Pellegrini M, Belz GT, Smyth GK, Febbraio MA, Nutt SL, Kallies A (2013). IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells. Nature Immunology 14, 1155-1165. [PubMed] [F1000] (Accepted 31 July, Epub 22 Sep 2013, Published 1 Nov 2013)
• Lee SCW, Phipson B, Hyland CD, Leong HS, Allan RS, Lun A, Hilton DJ, Nutt SL, Blewitt ME, Smyth GK, Alexander WS, Majewski IJ (2013). Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma. Blood 122, 2654-2663. [PubMed] (Accepted 13 Aug 2013, Epub 27 Aug 2013, Published 10 Oct 2013)
• Anders S, McCarthy DJ, Chen Y, Okoniewski M, Smyth GK, Huber W, Robinson MD (2013). Count-based differential expression analysis of RNA sequencing data using R and Bioconductor. Nature Protocols. 8, 1765-1786. [PubMed] [Preprint] (Accepted 23 May 2013, Published 1 Sep 2013)
• Vaillant F, Merino D, Lee L, Breslin K, Ritchie ME, Smyth GK, Christie M, Phillipson LJ, Burns CJ, Mann GB, Visvader JE, Lindeman GJ (2013). Targeting BCL-2 with the BH3 mimetic ABT-199 in ER-positive breast cancer. Cancer Cell 24, 120-129. [PubMed] (Accepted 4 Jun 2013, Published 8 Jul 2013)
• Wu D, Hu Y, Tong S Williams BRG, Smyth GK, Gantier MP (2013). The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease. RNA 19, 876-888. [PubMed] [Full Text] (Accepted 6 Apr 2013, Epub 24 May 2013, Published 1 Jul 2013)
• Phipson B, Lee S, Majewski IJ, Alexander WS, Smyth GK (2013). Empirical Bayes in the presence of exceptional cases, with application to microarray data. Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. [Preprint 22 May 2013] [arXiv:1602.08678 is a later version of this manuscript.]
• George, J, Alsop, K, Etemadmoghadam, D, Hondow, H, Mikeska, T, Dobrovic, A, The Australian Ovarian Cancer Study Group, Smyth, GK, Levine, DA, Mitchell, G, and David Bowtell, D (2013). Non-equivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations. Clinical Cancer Research 19, 3474-3484. [PubMed] (Accepted 27 Apr 2013, Epub 30 Apr 2013, Published 1 Jul 2013)
• George J#, Gorringe KL#, Smyth GK, Bowtell DDL (2013). Identifying associations between genomic alterations in tumors. Methods in Molecular Biology 1049, 9-19. [PubMed] [Full Text] (Accepted 21 Feb 2012, published Spring 2013)
• Smyth GK, Altman NS (2013). Separate-channel analysis of two-channel microarrays: recovering inter-spot information. BMC Bioinformatics 14, 165. [Full Text] (Accepted 10 May 2013, Published 26 May 2013)
• Liao Y, Smyth GK, Shi W (2013). The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote. Nucleic Acids Research 41(10), e108. [PubMed] [Full Text] [Software] (Accepted 8 Mar 2013, Epub 4 Apr 2013, Published 1 May 2013)
• Tang JZ, Carmichael CL, Shi W, Metcalf D, Ng AP, Hyland CD, Jenkins NA, Copeland NG, Howell VM, Zhao ZJ, Smyth GK, Kile BT, Alexander WS (2013). Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America 110, 6091-6096. [PubMed] (Accepted 12 Mar 2013, Epub 26 Mar 2013, Published 9 Apr 2013)
• Leong HS, Chen K, Hu Y, Lee S, Corbin J, Pakusch M, Murphy JM, Majewski IJ, Smyth GK, Alexander WS, Hilton DJ, Blewitt ME (2013). Epigenetic regulator Smchd1 functions as a tumor suppressor. Cancer Research 73, 1591-1599. [PubMed] (Accepted 22 Dec 2012, Epub 26 Dec 2012, Published 1 Mar 2013)
• Bolden JE, Shi W, Jankowski K, Kan C-Y, Cluse L, MacKenzie KL, Smyth GK, Johnstone, RW (2013). HDAC inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses. Cell Death and Disease 4, e519. [PubMed] (Accepted 31 Dec 2012, Published 28 Feb 2013)
• Pal B, Bouras T#, Shi W#, Vaillant F, Sheridan J, Fu N, Breslin K, Jiang K, Ritchie ME, Young M, Lindeman GJ*, Smyth GK*, Visvader JE (2013). Ezh2 coordinates global changes in the mammary epigenome induced by hormonal cues and controls mammary progenitor activity. Cell Reports 3, 411-326. [PubMed] (Accepted 1 Jan 2013, Epub 31 Jan 2013, Published 21 Feb 2013)

2012

• Lund SP, Nettleton D, McCarthy DJ, Smyth GK (2012). Detecting differential expression in RNA-sequence data using quasi-likelihood with shrunken dispersion estimates. Statistical Applications in Genetics and Molecular Biology Volume 11, Issue 5, Article 8. [PubMed] [Preprint PDF] (Accepted 31 Jul 2012, Published 22 Oct 2012)
• Wakim LM, Woodward-Davis A, Liu R, Hu Y, Villadangos J, Smyth GK, Bevan MJ (2012). The molecular signature of tissue resident memory CD8+ T cells isolated from the brain. Journal of Immunology 189, 3462-3471. [PubMed] (Accepted 30 Jul 2012, Epub 24 Aug 2012, Published 1 Oct 2012)
• Wu D, Smyth GK (2012). Camera: a competitive gene set test accounting for inter-gene correlation. Nucleic Acids Research 40, e133. [PubMed] (Accepted 1 May 2012, Epub 25 May 2012, Published 1 Sep 2012)
• Leong DW, Komen JC, Hewitt CA, Arnaud E, McKenzie M, Phipson B, Bahlo M, Laskowski A, Kinkel SA, Davey GM, Heath WR, Voss AK, Zahedi RP, Pitt JJ, Chrast R, Sickmann A, Ryan MT, Smyth GK, Thorburn DR, Scott HS (2012). Proteomic and metabolomic analyses of a mitochondrial complex I deficient mouse model generated by spontaneous B2 Short Interspersed Nuclear Element (SINE) insertion into the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene. Journal of Biological Chemistry 287, 20652-20663. [PubMed] (Accepted 23 Apr 2012, Epub 25 Apr 2012, Published 8 Jun 2012)
• Achtman AH, Pilat S, Law CW, Lynn DJ, Janot L, Mayer ML, Ma S, Kindrachuk J, Finlay BB, Brinkman FSL, Smyth GK, Hancock REW, Schofield, L (2012). Effective adjunctive therapy by an innate defense regulatory peptide in a pre-clinical model of severe malaria. Science Translational Medicine 4(135):135ra64. [PubMed] (Accepted 31 Mar 2012, Published 23 May 2012)
• Happo L, Phipson B, Smyth GK, Strasser A, Scott CL (2012). Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs. Cell Death and Disease 3, e306. [PubMed] (Accepted 29 Feb 2012, Published 10 May 2012)
• McCarthy DJ#, Chen Y#, Smyth GK (2012). Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Nucleic Acids Research 40, 4288-4297. [PubMed] (Accepted 10 Jan 2012, Epub 28 Jan 2012, Published 10 May 2012)
• Smyth GK (one of a panel of eight experts) (2012). Transcriptomics Technical Guide. Genome Technology Magazine, 1 April. (Accepted 25 Feb 2012, Published 1 Apr 2012)
• Oakes SR, Vaillant F, Lim E, Lee L, Breslin K, Feleppa F, Deb S, Ritchie ME, Takano E, Fox SB, Generali D, Smyth GK, Strasser A, Huang DCS, Visvader JE, Lindeman GJ (2011). Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3-mimetic ABT-737. Proceedings of the National Academy of Sciences of the United States of America 109, 2766-2771. [F1000] (Accepted 22 Jun 2012, Epub 18 Jul 2011, Published 21 Feb 2012)
• Young MD, McCarthy DJ, Wakefield MJ, Smyth GK, Oshlack A, Robinson MD (2012). Differential expression for RNA-Seq data: mapping, summarization, statistics and experimental design. Chapter 10 of Bioinformatics for High Throughput Sequencing (AM Aransay, ML Hackenberg and N Rodriguez-Ezpeleta, editors), Springer, New York, pages 169--190. [Publisher Site] (Accepted 28 Jun 2011, Epub 25 Oct 2011, Copyright year 2012)

2011

• Asselin-Labat M-L, Sutherland KD, Vaillant F, Gyorki DE, Wu D, Holroyd S, Breslin K, Ward T, Shi W, Bath ML, Deb S, Fox SB, Smyth GK, Lindeman GJ, Visvader JE (2011). Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. Molecular and Cellular Biology 31, 4609-4622. (Accepted 12 Sep 2011, Epub 19 Sep 2011, Published 1 Nov 2011).
• Kraft M, Cirstea IC, Voss AK, Thomas T, Goehring I, Sheikh B, Gordon L, Scott HS, Smyth GK, Ahmadian MR, Trautmann U, Zenker M, Tartaglia M, Ekici A, Reis A, Dörr H-G, Rauch A, Thiel CT (2011). Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling. Journal of Clinical Investigation 121, 3479-3491. [PubMed] (Accepted 8 Jun 2011, Epub 1 Aug 2011, Published 1 Sep 2011)
• Campbell DJ, Zhang Y, Kelly DJ, Gilbert RE, McCarthy DJ, Shi W, Smyth GK (2011). Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart. Clinical and Experimental Pharmacology and Physiology 38, 623-631. (Accepted 1 Jul 2011, Epub 7 Jul 2011, Published 1 Sep 2011)
• Ng AP, Loughran SJ, Metcalf D, Hyland CD, deGraaf CA, Hu Y, Smyth GK, Hilton DJ, Kile BT, Alexander WS (2011). Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood 118, 2454-2461. (Accepted 22 May 2011, Epub 14 Jun 2011, Published 1 Sep 2011)
• Hubert F-X, Kinkel SA, Davey GM, Phipson B, Mueller SN, Liston A, Proietto AI, Cannon PZF, Forehan S, Smyth GK, Wu L, Goodnow CC, Carbone FR, Scott HS, Heath WR (2011). Aire regulates transfer of antigen from mTEC to dendritic cells for induction of thymic tolerance. Blood 118(9), 2462-2472. (Accepted 23 Mar 2011, Epub 19 Apr 2011, Published 1 Sep 2011)
• Croker BA, O'Donnell JA, Nowell CJ, Metcalf D, Dewson G, Campbell KJ, Rogers KL, Hu Y, Smyth GK, Zhang JG, White M, Lackovic K, Cengia LH, O'Reilly LA, Bouillet P, Cory S, Strasser A, Roberts AW. (2011). Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1. Proceedings of the National Academy of Sciences of the United States of America 108, 13135-13140. (Accepted 10 Jul 2011, Epub 18 Jul 2011, Published 9 Aug 2011)
• Lahoud MH, Ahmet F, Kitsoulis S, Wan SS, Vremec D, Lee C-N, Phipson B, Shi W, Smyth GK, Lew AM, Kato Y, Mueller SN, Davey GM, Heath WR, Shortman K, Caminschi I (2011). Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype. Journal of Immunology 187, 842-850. (Accepted 18 May 2011, Epub 15 Jun 2011, Published 15 Jul 2011)
• Bryant PA, Smyth GK, Robins-Browne R, Curtis N (2011). Technical variability is greater than biological variability in a microarray experiment but both are outweighed by changes induced by stimulation. PLoS ONE 6, e19556. [PubMed] (Accepted 13 May 2011, Published 31 May 2011)
• Jackson JT, Hu Y, Liu R, Masson F, D'Amico A, Carotta S, Xin A, Camilleri MJ, Mount AM, Kallies A, Wu L, Smyth GK, Nutt SL, Belz GT (2011). Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages. The EMBO Journal 30, 2690-2704. (Accepted 28 Apr 2011, Published 17 May 2011)
• Gordon L Joo, JHE Andronikos, R Ollikainen, M Wallace, EM Umstad, MP, Permezel M, Oshlack A, Morley R, Carlin JB, Saffery R, Smyth GK, Craig JM (2011). Expression discordance of monozygotic twins at birth: Effect of intrauterine environment and a possible mechanism for fetal programming. Epigenetics 6, 579-592. [PubMed] (Accepted 5 Feb 2011, Published 1 May 2011)
• Helland Å#, Anglesio MS#, George J#, Cowin PA, Johnstone CN, House CM, Sheppard KE, Etemadmoghadam D, Melnyk N, Rustgi AK, Phillips WA, Johnsen H, Holm R, Kristensen GB, Australian Ovarian Cancer Study Group, Pearson RB, Børresen-Dale AL, Huntsman DG, deFazio A, Creighton CJ, Smyth GK, Bowtell DDL (2011). Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers. PLoS ONE 6, e18064. (Accepted 25 Feb 2011, Published 13 Apr 2011)
• Cretney E, Xin A, Shi W, Minnich M, Masson F, Miasari M, Belz G, Smyth GK, Meinrad Busslinger M, Nutt SL, Kallies A (2011). The transcription factors Blimp1 and IRF4 jointly control differentiation and function of effector regulatory T cells. Nature Immunology 12, 304-311. [PubMed] (Accepted 21 Jan 2011, Epub 6 Mar 2011, Published 1 Apr 2011)
• Zamudio NM, Scott HS, Wolski K, Lo C-Y, Law C, Leong D, Kinkel SA. Chong S, Jolley D, Smyth GK, de Kretser D, Whitelaw E, O’Bryan, MK (2011). DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription. PLoS ONE 6, e18276. [Full Text] (Accepted 1 Mar 2011, Published 31 Mar 2011)
• Ling K-H, Hewitt CA, Beissbarth T, Hyde L, Cheah P-S, Smyth GK, Tan S-S, Hahn CN, Thomas T, Thomas PQ, Scott HS (2011). Spatio-temporal regulation of multiple overlapping sense and novel natural antisense transcripts at the Nrgn and Camk2n1 gene loci during mouse cerebral corticogenesis. Cerebral Cortex 21, 683-697. [Publisher Full Text] (Accepted 30 Jun 2010, Epub 6 Aug 2010, Published 1 Mar 2011)

2010

• de Graaf CA, Kauppi M, Baldwin T, D Hyland C, Metcalf D, Willson TA, Carpinelli MR, Smyth GK, Alexander WS, Hilton DJ. (2010). Regulation of hematopoietic stem cells by their mature progeny. Proc Natl Acad Sci USA 107, 21689-21694. [Full Text] (Epub 29 Nov 2010, Published 14 Dec 2010)
• Happo L, Cragg MS, Phipson B, Haga JM, Jansen E, Herold MJ, Dewson G, Michalak EM, Vandenberg CJ, Smyth GK, Strasser A, Cory S, Scott CL (2010). Maximal killing of lymphoma cells by DNA-damage inducing therapy requires not only the p53 targets Puma and Noxa but also Bim. Blood 116, 5256-5267. (Accepted 21 Aug 2010, Epub 9 Sep 2010, Published 9 Dec 2010)
• Tan IKL, Mackin L, Wang N, Papenfuss AT, Elso CM, Ashton MP, Quirk F, Phipson B, Bahlo M, Speed TP, Smyth GK, Morahan G, Brodnicki TC (2010). A recombination hotspot leads to sequence variability within a novel gene and contributes to complex disease susceptibility. Genome Research 20, 1629-1638. (Accepted 24 Aug 2010, Epub 4 Nov 2010, Published 1 Dec 2010)
• Shi W, Oshlack A, Smyth GK (2010). Optimizing the noise versus bias trade-off for Illumina Whole Genome Expression BeadChips. Nucleic Acids Research 38, e204. [PubMed] (Accepted 16 Sep 2010, Epub 6 Oct 2010, Published 1 Dec 2010)
• Etemadmoghadam D, George J, Cowin PA, Cullinane C, Kansara M, Australian Ovarian Cancer Study Group, Gorringe, KL, Smyth, GK, Bowtell, DDL (2010). Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer. PLoS ONE 5(11), e15498. [PubMed] (Published 12 Nov 2010)
• Lindeman G, Smyth G, Visvader J, Wu D (2011). Gene expression profiles and uses thereof. International Patent Application No. PCT/AU2010/000524, Walter and Eliza Hall Institute of Medical Research 1G Royal Parade Parkville Melbourne, Victoria 3052, Australia. (Published 11 Nov 2010)
• Phipson B, Smyth GK (2010). Permutation p-values should never be zero: calculating exact p-values when permutations are randomly drawn. Statistical Applications in Genetics and Molecular Biology Volume 9, Issue 1, Article 39. [PubMed] [Reprint with Corrections] (Accepted 13 Sep 2010, Published 31 Oct 2010, Corrected 9 Feb 2011)
• Gorringe KL, George J, Anglesio MS, Ramakrishna M, Etemadmoghadam D, Cowin P, Sridhar A, Williams LH, Boyle SE, Yanaihara N, Okamoto A, Urashima M, Australian Ovarian Cancer Study, Smyth GK, Campbell IG, Bowtell DDL (2010). Copy number analysis identifies novel interactions between genomic loci in ovarian cancer. PLoS ONE 5(9): e11408. [PubMed] (Accepted 16 Apr 2010, Published 10 Sep 2010)
• Wu D, Lim E, Vaillant F, Asselin-Labat M-L, Visvader JE, Smyth GK (2010). ROAST: rotation gene set tests for complex microarray experiments. Bioinformatics 26, 2176-2182. [PubMed] (Accepted 4 Jul 2010, Epub 7 Jul 2010, Published 1 Sep 2010)
• Majewski IJ, Ritchie ME, Phipson B, Corbin J, Pakusch M, Ebert A, Busslinger M, Koseki H, Hu Y, Smyth GK, Alexander WS, Hilton DJ, Blewitt ME (2010). Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood 116, 731-739. [PubMed] (Accepted 21 Apr 2010, Epub 5 May 2010, Published 5 Aug 2010)
• Hewitt CA, Ling K-H, Merson TD, Simpson KM, Ritchie ME, King SL, Pritchard MA, Smyth GK, Thomas T, Scott HS, Voss AK (2010). Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of down syndrome. PLoS ONE 5, e11561. [PubMed] (Accepted 31 May 2010, Published 16 Jul 2010)
• Wentworth JM, Naselli G, Brown WA, Phipson B, Smyth GK, O’Brien PE, Harrison LC (2010). Pro-inflammatory CD11c⁺CD206⁺ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes 59, 1648-1656. [PubMed] (Accepted 16 Mar 2010, Epub 31 Mar 2010, Published 1 Jul 2010)
• Asselin-Labat M-L, Vaillant F, Sheridan J, Pal B, Wu D, Simpson ER, Yasuda H, Smyth GK, Martin TJ, Lindeman GJ, Visvader JE (2010). Control of mammary stem cell function by steroid hormone signaling. Nature 465, 798–802. [PubMed] [F1000] (Epub 11 Apr 2010, Published 10 Jun 2010)
• Sakthianandeswaren A, Curtis JM, Elso C, Kumar B, Baldwin TM, Lopaticki S, Kedzierski L, Smyth GK, Foote SJ, Handman E (2010). Fine Mapping of Leishmania major susceptibility locus lmr2 and evidence of a role for Fli1 in disease and wound healing. Infection and Immunity 78, 2734-2744. [PubMed] (Accepted 30 Mar 2010, Epub 5 Apr 2010, Published 1 Jun 2010)
• Guipponi M, Li Q-X, Hyde L, Beissbarth T, Smyth GK, Masters CL, Scott HS (2010). SAGE analysis of genes differentially expressed in pre-symptomatic TgSOD1G93A transgenic mice identified cellular processes involved in early stage of ALS pathology. Journal of Molecular Neuroscience 41, 172-182. [DOI] (Accepted 16 Nov 2009, Epub 2 Dec 2009, Published 1 May 2010)
• Shi W, de Graaf C, Kinkel S, Achtman A, Baldwin T, Schofield L, Scott HS, Hilton D, Smyth GK (2010). Estimating the proportion of microarray probes expressed in an RNA sample. Nucleic Acids Research 38, 2168-2176. [PubMed] (Accepted 12 Dec 2009, Epub 7 Jan 2010, Published 1 Apr 2010)
• Lim E#, Wu D#, Pal B#, Bouras T, Asselin-Labat M-L, Vaillant F, Yagita H, Lindeman GJ, Smyth GK, Visvader JE (2010). Transcriptome analyses of mouse and human mammary cell subpopulations reveals multiple conserved genes and pathways. Breast Cancer Research 12(2), R21. [PubMed] [F1000] (Published 26 Mar 2010)
• Young MD, Wakefield MJ, Smyth GK, Oshlack A (2010). Gene ontology analysis for RNA-seq: accounting for selection bias. Genome Biology 11(2), R14. [PubMed] (Published 4 Feb 2010)
• Robinson MD#, McCarthy DJ#, Smyth GK (2010). edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26(1), 139-140. [DOI] [PubMed] (Accepted 23 Oct 2009, Epub 11 Nov 2009, Published 1 Jan 2010)

2009

• Smyth GK, Verbyla AP (2009). Leverage adjustments for dispersion modelling in generalized nonlinear models. Australian and New Zealand Journal of Statistics 51(4), 433-448. [DOI] (Accepted 10 Nov 2008, Epub 19 Nov 2009, Published 1 Dec 2009)
• Shi W, Banerjee A, Ritchie ME, Gerondakis S, Smyth GK (2009). Illumina WG-6 BeadChip strips should be normalized separately. BMC Bioinformatics 10, 372. doi:10.1186/1471-2105-10-372 (Accepted 19 Oct 2009, Published 11 Nov 2009)
• Metcalf D, Ng AP, Loughran SJL, Phipson B, Smyth GK, Di Rago L, Mifsud S (2009). Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles. Proceedings of the National Academy of Sciences of the United States of America 106, 19102-19107. [Full Text] (Accepted 24 Sep 2009, Epub 23 Oct 2009, Published 10 Nov 2009)
• Liang D, Wong CE, Singh MB, Beveridge CA, Phipson B, Smyth GK, Bhalla PL (2009). Molecular dissection of pea shoot apical meristem. Journal Of Experimental Botany 60, 4201-4213. (Accepted 31 Jul 2009, Epub 25 Aug 2009, Published 14 Oct 2009)
• Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS (2009). Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 sense and antisense transcripts revealed by transcriptome profiling. Genome Biology 10, R104. [Full Text] (Accepted 25 Sep 2009, Published 2 Oct 2009)
• Smyth GK (one of a panel of 5 experts) (2009). Traditional and Digital Gene Expression. A trouble-shooting guide: experts share their advice on QPCR, microarrays and sequencing. Genome Technology Magazine, 30 Sep 2009, 16 pages.
• Hu Y, Smyth GK (2009). ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. Journal of Immunological Methods 347(1-2), 70-78. doi:10.1016/j.jim.2009.06.008 [Preprint PDF] (Accepted 20 Jun 2009, Epub 27 Jun 2009, Published 15 Aug 2009)
• Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat M-L, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ, kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ (2009). Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nature Medicine 15, 907-913. [Full Text] [F1000 Prime] (Published 2 Aug 2009)
• D'Costa K, Emslie D, Metcalf D, Smyth GK, Karnowski A, Kallies A, Nutt SL, Corcoran LM (2009). Blimp1 is limiting for transformation in a mouse plasmacytoma model. Blood 113(23), 5911-5919. [PubMed] (Epub 27 Mar 2009, Published 4 Jun 2009)
• Parish IA, Rao S, Smyth GK, Juelich T, Denyer GS, Davey GM, Strasser A, Heath WR (2009). The molecular signature of CD8+ T cells undergoing deletional tolerance. Blood 113, 4575-4585. [PubMed] (Epub 9 Feb 2009, Published 7 May 2009)
• Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK, Strasser A, Adams JM, Scott CL (2009). Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death and Differentiation 16, 684-696. [PubMed] (Epub 16 Jan 2009, Published May 2009).
• Hubert F-X, Kinkel SA, Crewther PE, Cannon PZF, Webster KE, Link M, Uibo R, Meager A, Forehan SP, Smyth GK, Mittaz L, Antonarakis SE, Peterson P, Heath WR, Scott HS (2009). Aire-deficient C57BL/6 mice mimicking the common human 13-bp deletion mutation present with only a mild autoimmune phenotype. Journal of Immunology 182, 3902-3918. [PubMed] (Published 1 Apr 2009)
• Silver JD, Ritchie ME, Smyth GK (2009). Microarray background correction: maximum likelihood estimation for the normal-exponential convolution. Biostatistics 10, 352-363. [PubMed] (Epub 8 Dec 2008, Published 1 Apr 2009)
• McCarthy DJ, Smyth GK (2009). Testing significance relative to a fold-change threshold is a TREAT. Bioinformatics 25, 765-771. [PubMed] (Epub 28 Jan 2009, Published 15 Mar 2009)
• Bryant PA, Smyth GK, Robins-Browne R, Curtis N (2009). Detection of gene expression in an individual cell type within a cell mixture using microarray analysis. PLoS ONE 4, e4427. [PubMed] (Published 12 Feb 2009)
• McMorran BJ, Marshall VM, de Graaf C, Drysdale KE, Shabbar M, Smyth GK, Corbin JE, Alexander WS, Foote SJ (2009). Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 323, 797-800. [PubMed] [F1000] (Published 6 Feb 2009)

2008

• Blekhman R, Oshlack A, Chabot AE, Smyth GK, Gilad Y (2008). Gene regulation in primates evolves under tissue-specific selection pressures. PLoS Genetics 4, e1000271. [PubMed] (Published 21 Nov 2008)
• Barker HE, Smyth GK, Wettenhall J, Ward TA, Bath ML, Lindeman GJ, Visvader JE (2008). Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland. BMC Developmental Biology 8, 94. [Full Text] (Published 1 Oct 2008)
• Michaud J, Simpson KM, Escher R, Buchet-Poyau K, Beissbarth T, Carmichael C, Ritchie ME, Schutz F, Cannon P, Liu M, Shen X, Ito Y, Raskind WH, Horwitz MS, Osato M, Turner DR, Speed TP, Kavallaris M, Smyth GK, Scott HS (2008). Integrative analysis of RUNX1 downstream pathways and target genes. BMC Genomics 9, 363. [PubMed] (Published 31 Jul 2008)
• Ellis L, Pan Y, Smyth GK, George DJ, McCormack C, Williams-Traux R, Mita M, Beck J, Ryan G, Atadja P, Butterfoss D, Dugan M, Culver K, Johnstone RW, Prince HM (2008). The histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T cell lymphoma. Clinical Cancer Research 14, 4500-4510. [Full Text] (Published 14 Jul 2008)
• Dwyer JP, Ritchie ME, Smyth GK, Harrap SB, Delbridge LMD, Domenighetti AA, Di Nicolantonio R (2008). Myocardial gene expression associated with genetic cardiac hypertrophy in the absence of hypertension. Hypertension Research 31, 941-955. [Full Text] (Accepted 28 Nov 2007, Published May 2008)
• Majewski IJ, Blewitt ME, de Graaf CA, McManus EJ, Bahlo M, Hilton AA, Hyland CD, Smyth GK, Corbin JE, Metcalf D, Alexander WS, Hilton DJ (2008). Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biology 6, e93. [Full Text] (Accepted 4 Mar 2008, Published 15 Apr 2008)
• Robinson MD, Smyth GK (2008). Small sample estimation of negative binomial dispersion, with applications to SAGE data. Biostatistics 9, 321-332. [DOI] [Preprint] (Accepted 19 Jul 2007, Epub 29 Aug 2007, Published 1 Apr 2008)
• Ling K-H, Hewitt CA, Kinkel SA, Smyth GK, Scott HS (2008). High-throughput and complex gene expression validation using the Universal Probe Library and the LightCycler 480 System. Biochemica No 2 (2008), 23-26. [Full Text] (Published 1 Mar 2008)
• Dunn PK, Smyth GK (2008). Evaluation of Tweedie exponential dispersion model densities by Fourier inversion. Statistics and Computing 18, 73-86. [DOI] [Preprint] (Accepted 15 Sep 2007, Epub 17 Oct 2007, Published 1 Mar 2008)
• Berkovic SF, Dibbens LM, Oshlack A, Silver JD, Katerelos M, Vears DF, Lüllmann-Rauch R, Blanz J, Zhang KW, Stankovich J, Kalnins RM, Dowling JP, Andermann E, Andermann F, Faldini E, D’Hooge R, Vadlamudi L, Macdonell RA, Hodgson BL, Bayly MA, Savige J, Mulley JC, Smyth GK, Power DA, Saftig P, Bahlo M (2008). Array-based gene discovery with 3 unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis. American Journal of Human Genetics 82(3), 673-684. [DOI] [PubMed] [Nature Review Genetics Research Highlight] (Accepted 28 Dec 2007, Published 28 Feb 2008)
• Pridans C, Holmes ML, Polli M, Wettenhall JM, Dakic A, Corcoran LM, Smyth GK, Nutt SL (2008). Identification of Pax5 target genes in early B cell differentiation. Journal of Immunology 180, 1719-1728. [PubMed] (Accepted 5 Dec 2007, Published 1 Feb 2008)
• Huggins CE, Domenighetti AA, Ritchie ME, Khalil N, Favaloro JM, Proietto J, Smyth GK, Pepe S, Delbridge LMD (2008). Functional and metabolic remodelling in GLUT4-deficient hearts confers hyper-responsiveness to substrate intervention. Journal of Molecular and Cellular Cardiology 44, 270-280. (Accepted 30 Nov 2007, Published 1 Feb 2008)

2007

• Robinson MD, Smyth GK (2007). Moderated statistical tests for assessing differences in tag abundance. Bioinformatics 23, 2881-2887. [PubMed] [Supplementary information] [Software] (Epub 19 Sep 2007, Published 1 Nov 2007)
• Ritchie ME, Silver J, Oshlack A, Holmes M, Diyagama D, Holloway A, Smyth GK (2007). A comparison of background correction methods for two-colour microarrays. Bioinformatics 23, 2700-2707. [PubMed] [Supplementary Information] (Epub 25 Aug 2007, Published 15 Oct 2007)
• Baldwin T, Sakthianandeswaren A, Curtis J, Kumar B, Smyth GK, Foote S, Handman E (2007). Wound healing response is a major contributor to the severity of cutaneous leishmaniasis in the ear model of infection. Parasite Immunology 29, 501-513. [PubMed] (Accepted 25 Jul 2007, Published 1 Oct 2007).
• Smyth, G. K. (one of a panel of 9 experts) (2007). The cDNA Microarray Tech Guide. Genome Technology Magazine, Supplement April 2007, pages 1-15. [PDF] (Published 2 Apr 2007)
• Oshlack A, Chabot AE, Smyth GK, Gilad Y (2007). Using DNA microarrays to study gene expression in closely related species. Bioinformatics 23, 1235-1242. [PubMed] (Published 23 Mar 2007)
• Greenawalt D. M., Duong C., Smyth G. K., Ciavarella M. L., Thompson N. J., Tiang T., Murray W. K., Thomas R. J S., Phillips W. A. (2007). Gene expression profiling of esophageal cancer: comparative analysis of Barrett's esophagus, adenocarcinoma and squamous cell carcinoma. International Journal of Cancer 120, 1914-1921. [PubMed] (Published 1 May 2007)
• Oshlack A, Emslie D, Corcoran L, Smyth, GK (2007). Normalization of boutique two-color microarrays with a high proportion of differentially expressed probes. Genome Biology 8, R2. [PubMed] (Published 4 Jan 2007)

2006

• Holloway AJ, Oshlack A, Diyagama DS, Bowtell DDL, Smyth GK (2006). Statistical analysis of an RNA titration series evaluates microarray precision and sensitivity on a whole-array basis. BMC Bioinformatics 7, Article 511. [PubMed] [Data and Supplementary Information] (Published 22 Nov 2006)
• Wormald S, Hilton DJ, Smyth GK, Speed TP (2006). Proximal genomic localization of STAT1 binding and regulated transcriptional activity. BMC Genomics 7, 254. [PubMed] (Published 11 Oct 2006)
• Smyth GK (2006). Optimization. Encyclopedia of Environmetrics, John Wiley & Sons. [DOI] [PDF] (Originally published 15 Jan 2002, republished in the online edition 15 Sep 2006)
• Smyth GK (2006). Nonlinear Regression. Encyclopedia of Environmetrics, John Wiley & Sons. [DOI] [PDF] (Originally published 15 Jan 2002, republished in the online edition 15 Sep 2006)
• Lahoud M. H., Proietto A. I., Gartlan K., Kitsoulis S., Curtis J., Wettenhall J., Sofi M., Daunt M., O'Keeffe M., Caminschi I., Satterley, K. Rizzitelli, A. Schnorrer, P. Hinohara, A. Yamaguchi, Y. Wu, L., Smyth G. K., Handman E., Shortman K., Wright M. D. (2006). Signal regulatory protein molecules are differentially expressed by CD8-dendritic cells. Journal of Immunology 177, 372-382. [PubMed] (Published 1 Jul 2006)
• Ritchie ME, Diyagama D, Neilson J, van Laar R, Dobrovic A, Holloway A, Smyth GK (2006). Empirical array quality weights in the analysis of microarray data. BMC Bioinformatics 7, Article 261. [PubMed] [Full Text] [Supplementary Information] (Published 19 May 2006)
• de Silva MG, Hildebrand MS, Christopoulos H, Newman MR, Bell K, Ritchie ME, Smyth GK, Dahl HHM (2006). Gene expression changes during step-wise differentiation of embryonic stem cells along the inner ear hair cell pathway. Acta Oto-Laryngologica 126, 1148-1157. [PubMed] (Epub 12 May 2006, Published 1 Dec 2006)
• Wettenhall JM, Simpson KM, Satterley K, Smyth GK (2006). affylmGUI: a graphical user interface for linear modeling of single channel microarray data. Bioinformatics 22, 897-899. [PubMed] (Published 1 Apr 2006)
• Gilad Y, Oshlack A, Smyth GK, Speed TP, White KP (2006). Expression profiling in primates reveals a rapid evolution of human transcription factors. Nature 440, 242-245. [DOI [F1000Prime] (Accepted 28 Dec 2005, Published 9 Mar 2006)
• Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat M-L, Wu L, Lindeman GJ, Visvader JE (2006). Generation of a functional mammary gland from a single stem cell. Nature 439, 84-88. [DOI] [F1000Prime] (Accepted 13 Oct 2005, Published 5 Jan 2006)

2005

• Dunn PK, Smyth GK (2005). Series evaluation of Tweedie exponential dispersion models. Statistics and Computing 15, 267-280. [Preprint PDF] (Accepted 1 Mar 2005, Published 1 Oct 2005)
• Smyth GK (2005). Limma: linear models for microarray data. In: Bioinformatics and Computational Biology Solutions using R and Bioconductor, R. Gentleman, V. Carey, S. Dudoit, R. Irizarry, W. Huber (eds.), Springer, New York, pages 397-420. [DOI] [Preprint PDF] (Published 8 Aug 2005)
• Ritchie ME, Smyth GK (2005). Estimating shared parameters using many small data sets. In: Statistical Solutions to Modern Problems: Proceedings of the 20th International Workshop on Statistical Modelling, Sydney, 10-15 Jul 2005, Francis, A., Matawie, K., Oshlack, A., and Smyth, G. K. (eds.), University of Western Sydney Press, pages 419-427. (Published 10 Jul 2005)
• Beißbarth T, Tye-Din JA, Smyth GK, Anderson RP, Speed TP (2005). Modelling and analysis of T-cell epitope screening data. In: Statistical Solutions to Modern Problems: Proceedings of the 20th International Workshop on Statistical Modelling, Sydney, 10-15 Jul 2005. Francis, A., Matawie, K., Oshlack, A., and Smyth, G. K. (eds.), University of Western Sydney Press, pages 101-108. (Published 10 Jul 2005)
• Francis A, Matawie K, Oshlack A, Smyth GK (2005). Statistical Solutions to Modern Problems: Proceedings of the 20th International Workshop on Statistical Modelling, Sydney, 10-15 Jul 2005. University of Western Sydney Press, Sydney, ISBN 1-74108-101-7. (Published 10 Jul 2005)
• Dwyer JP, Ritchie ME, Smyth GK, Delbridge LM, Domenighetti AA, Harrap SB, Di Nicolantonio R (2005). Differentially expressed genes in cardiac tissue from the hypertrophic heart rat. Clinical and Experimental Pharmacology and Physiology 32 (7), A13-A14. (Meeting abstract, Published July 2005)
• Beissbarth T, Tye-Din JA, Smyth GK, Speed TP, Anderson RP (2005). A systematic approach for comprehensive T-cell epitope discovery using peptide libraries. Bioinformatics 21 (Supplement 1), i29-i37. [Publisher Full Text] (Published 7 Jun 2005)
• Smyth GK, Michaud J, Scott HS (2005). Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 21(9), 2067-2075. [PubMed] [Supplementary Information] [Preprint PDF] [Errata] [Faculty1000Prime] (Epub 18 Jan 2005, Published 1 May 2005)
• Smyth GK (2005). Individual channel analysis of two-colour microarray data. Invited Session IPM 11: Computational Tools For Microarray Analysis, 55th Session of the International Statistics Institute, 5-12 Apr 2005, Sydney Convention & Exhibition Centre, Sydney, Australia (CD Paper 116). (PDF) (Published 5 Apr 2005)
• Peart MJ, Smyth GK, van Laar RK, Richon VM, Holloway AJ, Johnstone RW (2005). Identification and functional significance of genes regulated by structurally diverse histone deacetylase inhibitors. Proceedings of the National Academy of Sciences of the United States of America 102, 3697-3702. [DOI] (Published 8 Mar 2005)
• Cox ME, Moss A, Smyth GK (2005). Water quality condition and trend in North Queensland waterways. Marine Pollution Bulletin 51, 89-98. [DOI] (Published March 2005)
• Smyth GK (2005). Polynomial approximation. In: Encyclopedia of Biostatistics Second Edition, Volume 6, P. Armitage and T. Colton (eds.), Wiley, London, pages 4136-4140. [DOI] [Preprint PDF] (Published 15 Jul 2005)
• Smyth GK (2005). Optimization and nonlinear equations. In: Encyclopedia of Biostatistics Second Edition, Volume 6, P. Armitage and T. Colton (eds.), Wiley, London, pages 3857-3863. [DOI] [PDF (Published 15 Jul 2005)
• Smyth GK (2005). Numerical integration. In: Encyclopedia of Biostatistics Second Edition, Volume 6, P. Armitage and T. Colton (eds.), Wiley, London, pages 3766-3773. [DOI] [PDF] (Published 15 Jul 2005)
• Smyth GK (2005). Numerical analysis. In: Encyclopedia of Biostatistics Second Edition, Volume 6, P. Armitage and T. Colton (eds.), Wiley, London, pages 3762-3766. [DOI] PDF (Published 15 Jul 2005)
• Maindonald JH, Smyth GK (2005). Matrix computations. In: Encyclopedia of Biostatistics Second Edition, Volume 5, P. Armitage and T. Colton (eds.), Wiley, London, 8 pages. [DOI] [PDF] (Published 15 Jul 2005)

2004

• Boon WM, Beissbarth T, Hyde L, Smyth GK, Gunnersen J, Denton DA, Scott HS, Tan SS (2004). A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering. Proceedings of the National Academy of Sciences of the United States of America 101, 14972–14977. [PubMed] (Published 12 Oct 2004)
• Podlich HM, Faddy MJ, Smyth GK (2004). Semi-parametric extended Poisson process models. Statistics and Computing 14, 311-321. [DOI] [Preprint PDF] (Published Oct 2004)
• Gentleman RC, Cary VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth GK, Tierney L, Yang YH, Zhang J (2004). Bioconductor: open software development for computational biology and bioinformatics. Genome Biology 5, R80. [PubMed] (Published 15 Sep 2004)
• Wettenhall JM, Smyth GK (2004). limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics 20, 3705-3706. [PubMed] (Published 5 Aug 2004)
• Beissbarth T, Hyde L, Smyth GK, Job C, Boon WM, Tan SS, Scott HS, Speed TP (2004). Statistical modeling of sequencing errors in SAGE libraries. Bioinformatics 20 Supplement 1, i31-i39. [PubMed] (Published 1 Aug 2004)
• Domenighetti AA, Ritchie M, Smyth GK, Pedrazzini T, Proietto J, Delbridge LMD (2004). Gene expression profiling reveals distinct sets of genes altered during hormonally and metabolically induced cardiac hypertrophies. Journal of Molecular and Cellular Cardiology 37 (1), 303-304. (Meeting abstract, Published 1 Jul 2004)
• Elso C, Kumar B, Smyth GK, Foote S, Handman E (2004). Dissociation of disease susceptibility, inflammation and cytokine profile in lmr1/2 congenic mice infected with Leishmania major. Genes and Immunity 5, 188-196. (Published 1 May 2004)
• Elso CM, Roberts LJ, Smyth GK, Thomson RJ, Baldwin TM, Foote SJ, Handman E (2003). Leishmaniasis host response loci (lmr1–3) modify disease severity through a Th1/Th2-independent pathway. Genes and Immunity 5, 93-100. [PubMed] (Published 1 Mar 2004)
• Smyth GK (2004). Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Statistical Applications in Genetics and Molecular Biology 3(1), Article 3. [DOI] [PubMed] [Preprint PDF with corrections] (Published 12 Feb 2004)

2003

• Smyth GK, Speed TP (2003). Normalization of cDNA microarray data. Methods 31(4), 265-273. [DOI] [PubMed] [Preprint PDF] (Published 1 Dec 2003)
• Smyth GK (2003). Pearson's goodness of fit statistic as a score test statistic. In: Science and Statistics: A Festschrift for Terry Speed, D. R. Goldstein (ed.), IMS Lecture Notes - Monograph Series, Volume 40, Institute of Mathematical Statistics, Beachwood, Ohio, pages 115-126. [Preprint PDF] (Published March 2003)
• Smyth GK, Yang YH, Speed TP (2003). Statistical issues in cDNA microarray data analysis. Methods in Molecular Biology 224, 111-136. [PubMed] [Full Text PDF] [Preprint PDF] (Published March 2003)

Earlier Publications

• Publications up to 2002

Epub = Electronic Publication ahead of print (aka Advance Online Publication).
# = equal first author (contributed equally)
* = equal senior author (contributed equally)
Publications on this page are in reverse chronological order of publication (starting from most recent).